doi: 10.1016/s0960-9822(02)01433-1.
Apoptosis: mitochondrial membrane permeabilization--the (w)hole story?
Affiliations
- PMID: 12546810
- DOI: 10.1016/s0960-9822(02)01433-1
Item in Clipboard
Apoptosis: mitochondrial membrane permeabilization--the (w)hole story?
Curr Biol.
.
Free article
Abstract
One critical step of apoptosis is the release of mitochondrial proteins through the outer mitochondrial membrane. Recent work shows that two pro-apoptotic Bcl-2 family proteins, Bax and Bid, as well as the mitochondrion-specific lipid cardiolipin may cooperate in chemically defined liposomes to generate a protein-permeable conduit, relaunching the debate on the identity of the pore responsible for mitochondrial membrane permeabilization during apoptosis.
Similar articles
-
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.Cell. 2002 Nov 1;111(3):331-42. doi: 10.1016/s0092-8674(02)01036-x. Cell. 2002. PMID: 12419244
-
Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.Biochem J. 2015 May 1;467(3):495-505. doi: 10.1042/BJ20141291. Biochem J. 2015. PMID: 25714678
-
Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis.Curr Opin Cell Biol. 2000 Aug;12(4):414-9. doi: 10.1016/s0955-0674(00)00110-1. Curr Opin Cell Biol. 2000. PMID: 10873816 Review.
-
Inhibition of Bax-induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol.J Neurosci. 2003 Apr 1;23(7):2735-43. doi: 10.1523/JNEUROSCI.23-07-02735.2003. J Neurosci. 2003. PMID: 12684459 Free PMC article.
-
Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis.Chem Phys Lipids. 2014 Apr;179:70-4. doi: 10.1016/j.chemphyslip.2013.12.002. Epub 2013 Dec 12. Chem Phys Lipids. 2014. PMID: 24333953 Review.
Cited by
-
Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis.Mol Biol Rep. 2021 Mar;48(3):2351-2364. doi: 10.1007/s11033-021-06267-3. Epub 2021 Mar 18. Mol Biol Rep. 2021. PMID: 33738723
-
Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death.Cell Death Differ. 2004 Dec;11(12):1277-86. doi: 10.1038/sj.cdd.4401485. Cell Death Differ. 2004. PMID: 15297883 Free PMC article.
-
Protection of cisplatin cytotoxicity by an inactive cyclin-dependent kinase.Am J Physiol Renal Physiol. 2010 Jul;299(1):F112-20. doi: 10.1152/ajprenal.00151.2010. Epub 2010 May 5. Am J Physiol Renal Physiol. 2010. PMID: 20444741 Free PMC article.
-
Spatial and temporal changes in Bax subcellular localization during anoikis.J Cell Biol. 2003 Aug 18;162(4):599-612. doi: 10.1083/jcb.200302154. J Cell Biol. 2003. PMID: 12925707 Free PMC article.
-
Viruses as modulators of mitochondrial functions.Adv Virol. 2013;2013:738794. doi: 10.1155/2013/738794. Epub 2013 Oct 24. Adv Virol. 2013. PMID: 24260034 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
