doi: 10.1016/s0960-9822(02)01433-1.
Apoptosis: mitochondrial membrane permeabilization--the (w)hole story?
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- PMID: 12546810
- DOI: 10.1016/s0960-9822(02)01433-1
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Apoptosis: mitochondrial membrane permeabilization--the (w)hole story?
Curr Biol.
.
Free article
Abstract
One critical step of apoptosis is the release of mitochondrial proteins through the outer mitochondrial membrane. Recent work shows that two pro-apoptotic Bcl-2 family proteins, Bax and Bid, as well as the mitochondrion-specific lipid cardiolipin may cooperate in chemically defined liposomes to generate a protein-permeable conduit, relaunching the debate on the identity of the pore responsible for mitochondrial membrane permeabilization during apoptosis.
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