Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment
- PMID: 12492502
- DOI: 10.1046/j.1432-0436.2002.700914.x
Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment
Abstract
Matrix metalloproteinases (MMPs) have long been thought of as critical factors regulating matrix degradation associated with cell invasion into ectopic tissue compartments during primary tumor growth and metastasis. One member of the MMP family historically linked to these invasive processes is MMP-9/gelatinase B. By studying a transgenic mouse model of de novo epithelial carcinogenesis, new roles for MMP-9 have emerged that broaden the view of its functional contribution to malignant progression. The combined implication of these studies suggest that MMP-9 functionally contributes to cancer development; however, its major regulatory role may be in its ability to activate poorly diffusible and/or matrix-sequestered growth factors that regulate epithelial and/or endothelial cell growth as opposed to regulating cellular invasion across basement membranes.
Similar articles
-
Expression of matrix metalloproteinases (MMP-2, MMP-9, MT1-MMP) and their inhibitors (TIMP-1, TIMP-2) in common epithelial tumors of the ovary.Int J Oncol. 2000 Oct;17(4):673-81. Int J Oncol. 2000. PMID: 10995877
-
Expression of matrix metalloproteinase-2 and -9 and their inhibitors, tissue inhibitor of metalloproteinase-1 and -2, in primary cultures of human prostatic stromal and epithelial cells.J Cell Physiol. 2002 May;191(2):208-16. doi: 10.1002/jcp.10092. J Cell Physiol. 2002. PMID: 12064464
-
Prominent expression of metalloproteinases in early stages of ovarian tumorigenesis.Mol Carcinog. 2007 Feb;46(2):130-43. doi: 10.1002/mc.20273. Mol Carcinog. 2007. PMID: 17131304
-
Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells.Differentiation. 2002 Dec;70(9-10):486-97. doi: 10.1046/j.1432-0436.2002.700903.x. Differentiation. 2002. PMID: 12492491 Review.
-
Matrix metalloproteinase-induced malignancy in mammary epithelial cells.Cells Tissues Organs. 2007;185(1-3):104-10. doi: 10.1159/000101310. Cells Tissues Organs. 2007. PMID: 17587815 Review.
Cited by
-
A weighty problem: metabolic perturbations and the obesity-cancer link.Horm Mol Biol Clin Investig. 2015 Aug;23(2):47-57. doi: 10.1515/hmbci-2015-0022. Horm Mol Biol Clin Investig. 2015. PMID: 26167982 Free PMC article. Review.
-
Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor.Int J Cancer. 2011 Jan 15;128(2):283-93. doi: 10.1002/ijc.25326. Epub 2010 Mar 15. Int J Cancer. 2011. PMID: 20232379 Free PMC article.
-
Lack of c-kit receptor promotes mammary tumors in N-nitrosomethylurea-treated Ws/Ws rats.Cancer Cell Int. 2008 Apr 29;8:5. doi: 10.1186/1475-2867-8-5. Cancer Cell Int. 2008. PMID: 18445266 Free PMC article.
-
The epigenetic reprogramming of poorly aggressive melanoma cells by a metastatic microenvironment.J Cell Mol Med. 2006 Jan-Mar;10(1):174-96. doi: 10.1111/j.1582-4934.2006.tb00299.x. J Cell Mol Med. 2006. PMID: 16563230 Free PMC article.
-
Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes.FASEB J. 2005 Feb;19(2):234-6. doi: 10.1096/fj.04-2140fje. Epub 2004 Nov 18. FASEB J. 2005. PMID: 15550552 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous
