Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Dec;132(6):831-9.
doi: 10.1093/oxfordjournals.jbchem.a003294.

Protein kinase C delta (PKC delta): activation mechanisms and functions

Ushio Kikkawa  1 , Hidenori Matsuzaki, Toshiyoshi Yamamoto
Affiliations
Free article
Review

Protein kinase C delta (PKC delta): activation mechanisms and functions

Ushio Kikkawa et al. J Biochem. 2002 Dec.
Free article

Abstract

Protein kinase C (PKC)delta was the first new/novel PKC isoform to be identified by the screening of mammalian cDNA libraries, based on the structural homology of its nucleotide sequences with those of classical/conventional PKC isoforms. PKC delta is expressed ubiquitously among cells and tissues. It is activated by diacylglycerol produced by receptor-mediated hydrolysis of membrane inositol phospholipids as well as by tumor-promoting phorbol ester through the binding of these compounds to the C1 region in its regulatory domain. It is also cleaved by caspase to generate a catalytically active fragment, and it is converted to an active form without proteolysis through the tyrosine phosphorylation reaction. Various lines of evidence indicate that PKC delta activated in distinct ways plays critical roles in cellular functions such as the control of growth, differentiation, and apoptosis. This article briefly summarizes the regulatory mechanisms of PKC delta activity and its functions in cell signaling.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles