Vascular endothelial growth factor-C expression in human gallbladder cancer and its relationship to lymph node metastasis
- PMID: 12469214
Vascular endothelial growth factor-C expression in human gallbladder cancer and its relationship to lymph node metastasis
Abstract
Lymph node metastasis is a major prognostic factor in human cancer. Vascular endothelial growth factor C (VEGF-C) is a lymphangiogenic polypeptide that has been implicated in several human solid tumors. However, the clinical significance of VEGF-C has remained unknown in gallbladder carcinoma. Paraffin-embedded tumor specimens of 52 surgically resected gallbladder cancers were immunohistochemically stained for VEGF-C, VEGF, and CD34. The correlations among VEGF-C expression, VEGF expression, microvessel density (MVD), clinicopathologic features, and clinical outcomes were statistically analyzed. Thirty-three (63%) of the 52 gallbladder cancers were highly positive for VEGF-C protein by immunohistochemistry. VEGF-C expression was significantly correlated with lymphatic vessel involvement, lymph node metastasis, and worse outcomes after operation (p<0.001, p<0.001, p<0.001, respectively), but not with MVD. By the Cox regression model, lymphatic vessel involvement emerged as an independent prognostic parameter. These results suggest that VEGF-C may play a role in tumor progression via lymphangiogenesis and lymph node metastasis in human gallbladder cancer.
Similar articles
-
Vascular endothelial growth factor-C (VEGF-C) expression predicts lymph node metastasis of transitional cell carcinoma of the bladder.Int J Urol. 2005 Feb;12(2):152-8. doi: 10.1111/j.1442-2042.2005.01010.x. Int J Urol. 2005. PMID: 15733109
-
Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) in esophageal squamous cell carcinoma.Anticancer Res. 2002 Nov-Dec;22(6C):3977-84. Anticancer Res. 2002. PMID: 12553021
-
[Expression of vascular endothelial growth factors (VEGF)-A, -C and -D and their prognostic significance and relationship with angio- and lymphangiogenesis in gastric cancer].Zhonghua Zhong Liu Za Zhi. 2008 Nov;30(11):837-43. Zhonghua Zhong Liu Za Zhi. 2008. PMID: 19173829 Chinese.
-
Molecular control of lymphatic metastasis.Ann N Y Acad Sci. 2008;1131:225-34. doi: 10.1196/annals.1413.020. Ann N Y Acad Sci. 2008. PMID: 18519975 Review.
-
[Review of relationship between vascular endothelial growth factor C & D and lymph node metastasis of malignant tumor].Ai Zheng. 2002 Jun;21(6):696-700. Ai Zheng. 2002. PMID: 12452077 Review. Chinese.
Cited by
-
Expression of vascular endothelial growth factor and its receptors VEGFR-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas.World J Gastroenterol. 2006 Oct 14;12(38):6182-7. doi: 10.3748/wjg.v12.i38.6182. World J Gastroenterol. 2006. PMID: 17036392 Free PMC article.
-
Safety and efficacy of afatinib as add-on to standard therapy of gemcitabine/cisplatin in chemotherapy-naive patients with advanced biliary tract cancer: an open-label, phase I trial with an extensive biomarker program.BMC Cancer. 2019 Jan 11;19(1):55. doi: 10.1186/s12885-018-5223-7. BMC Cancer. 2019. PMID: 30634942 Free PMC article. Clinical Trial.
-
Serum vascular endothelial growth factors C and D as forecast tools for patients with gallbladder carcinoma.Tumour Biol. 2015 Aug;36(8):6305-12. doi: 10.1007/s13277-015-3316-3. Epub 2015 Mar 24. Tumour Biol. 2015. PMID: 25801241 Free PMC article.
-
Combined histomorphometric and gene-expression profiling applied to toxicology.Genome Biol. 2003;4(5):R32. doi: 10.1186/gb-2003-4-5-r32. Epub 2003 Apr 30. Genome Biol. 2003. PMID: 12734012 Free PMC article.
-
Impact of lymph node micrometastasis in hilar bile duct carcinoma patients.World J Gastroenterol. 2006 Apr 28;12(16):2549-55. doi: 10.3748/wjg.v12.i16.2549. World J Gastroenterol. 2006. PMID: 16688800 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
