Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Jan;13(1):5-14.
doi: 10.1093/cercor/13.1.5.

Interlaminar connections in the neocortex

Alex M Thomson  1 , A Peter Bannister
Affiliations
Review

Interlaminar connections in the neocortex

Alex M Thomson et al. Cereb Cortex. 2003 Jan.

Abstract

This review summarizes the local circuit, interlaminar connections in adult mammalian neocortex. These were first demonstrated with anatomical techniques, which indicate some of the exquisite spatial precision present in the circuitry. Details, such as the class(es) of neurons targeted by some of these projections, have begun to be added in studies that combine paired/triple intracellular recordings with dye-filling of connected neurons. Clear patterns are emerging from these studies, with 'forward' projections from layer 4 to 3 and from 3 to 5 targeting both selected pyramidal cells and interneurons, while 'back' projections from layer 5 to 3 and from 3 to 4 target only interneurons. To place these data in a wider context, the major afferent inputs to and efferent outputs from each of the layers are discussed first.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Local connectivity and synaptic dynamics in mouse and human neocortex.
    Campagnola L, Seeman SC, Chartrand T, Kim L, Hoggarth A, Gamlin C, Ito S, Trinh J, Davoudian P, Radaelli C, Kim MH, Hage T, Braun T, Alfiler L, Andrade J, Bohn P, Dalley R, Henry A, Kebede S, Alice M, Sandman D, Williams G, Larsen R, Teeter C, Daigle TL, Berry K, Dotson N, Enstrom R, Gorham M, Hupp M, Dingman Lee S, Ngo K, Nicovich PR, Potekhina L, Ransford S, Gary A, Goldy J, McMillen D, Pham T, Tieu M, Siverts L, Walker M, Farrell C, Schroedter M, Slaughterbeck C, Cobb C, Ellenbogen R, Gwinn RP, Keene CD, Ko AL, Ojemann JG, Silbergeld DL, Carey D, Casper T, Crichton K, Clark M, Dee N, Ellingwood L, Gloe J, Kroll M, Sulc J, Tung H, Wadhwani K, Brouner K, Egdorf T, Maxwell M, McGraw M, Pom CA, Ruiz A, Bomben J, Feng D, Hejazinia N, Shi S, Szafer A, Wakeman W, Phillips J, Bernard A, Esposito L, D'Orazi FD, Sunkin S, Smith K, Tasic B, Arkhipov A, Sorensen S, Lein E, Koch C, Murphy G, Zeng H, Jarsky T. Campagnola L, et al. Science. 2022 Mar 11;375(6585):eabj5861. doi: 10.1126/science.abj5861. Epub 2022 Mar 11. Science. 2022. PMID: 35271334 Free PMC article.
  • Local circuits targeting parvalbumin-containing interneurons in layer IV of rat barrel cortex.
    Staiger JF, Zuschratter W, Luhmann HJ, Schubert D. Staiger JF, et al. Brain Struct Funct. 2009 Dec;214(1):1-13. doi: 10.1007/s00429-009-0225-5. Epub 2009 Oct 31. Brain Struct Funct. 2009. PMID: 19882169 Free PMC article.
  • Layer 3 Dynamically Coordinates Columnar Activity According to Spatial Context.
    Plomp G, Larderet I, Fiorini M, Busse L. Plomp G, et al. J Neurosci. 2019 Jan 9;39(2):281-294. doi: 10.1523/JNEUROSCI.1568-18.2018. Epub 2018 Nov 20. J Neurosci. 2019. PMID: 30459226 Free PMC article.
  • Subplate in the developing cortex of mouse and human.
    Wang WZ, Hoerder-Suabedissen A, Oeschger FM, Bayatti N, Ip BK, Lindsay S, Supramaniam V, Srinivasan L, Rutherford M, Møllgård K, Clowry GJ, Molnár Z. Wang WZ, et al. J Anat. 2010 Oct;217(4):368-80. doi: 10.1111/j.1469-7580.2010.01274.x. Epub 2010 Aug 18. J Anat. 2010. PMID: 20727056 Free PMC article.
  • The neocortical microcircuit as a tabula rasa.
    Kalisman N, Silberberg G, Markram H. Kalisman N, et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):880-5. doi: 10.1073/pnas.0407088102. Epub 2005 Jan 3. Proc Natl Acad Sci U S A. 2005. PMID: 15630093 Free PMC article.
See all "Cited by" articles

Publication types

LinkOut - more resources