Review
doi: 10.1038/nrm972.
Immunoglobulin transport across polarized epithelial cells
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- PMID: 12461560
- DOI: 10.1038/nrm972
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Review
Immunoglobulin transport across polarized epithelial cells
Nat Rev Mol Cell Biol.
2002 Dec.
Abstract
IgA, IgG and IgM are transported across epithelial cells in a receptor-mediated process known as transcytosis. In addition to neutralizing pathogens in the lumen of the gastrointestinal, respiratory and urogenital tracts, these antibody-receptor complexes are now known to mediate intracellular neutralization of pathogens and might also be important in immune activation and tolerance. Recent studies on the intracellular transport pathways of antibody-receptor complexes and antibody-stimulated receptor-mediated transcytosis are providing new insight into the nature and regulation of endocytic pathways.
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