Review
doi: 10.1038/nrc946.
Polyoma virus middle T antigen and its role in identifying cancer-related molecules
Affiliations
- PMID: 12459733
- DOI: 10.1038/nrc946
Item in Clipboard
Review
Polyoma virus middle T antigen and its role in identifying cancer-related molecules
Nat Rev Cancer.
2002 Dec.
Abstract
Most cancer researchers take for granted some of the basic concepts about the molecular changes that underlie tumorigenesis. These include the principles that tyrosine kinases and the phosphorylation of phosphatidylinositol by phosphatidylinositol 3-kinases are important in the signalling pathways that control proliferation and apoptosis, and hence cancer formation. However, how many know that a small DNA mouse virus was crucial in establishing both of these tenets?
Similar articles
-
Cell transformation by the middle T-antigen of polyoma virus.Oncogene. 2001 Nov 26;20(54):7908-16. doi: 10.1038/sj.onc.1204859. Oncogene. 2001. PMID: 11753673 Review.
-
Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.Virology. 2009 Feb 20;384(2):304-16. doi: 10.1016/j.virol.2008.09.042. Epub 2008 Nov 20. Virology. 2009. PMID: 19022468 Free PMC article. Review.
-
Interference of mouse polyomavirus with the c-myc gene and its product in mouse mammary adenocarcinomas.Int J Oncol. 2003 Aug;23(2):333-41. Int J Oncol. 2003. PMID: 12851682
-
Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling.Oncogene. 2006 Jan 5;25(1):32-42. doi: 10.1038/sj.onc.1209013. Oncogene. 2006. PMID: 16170362
-
Suppression of AP-1 constitutive activity interferes with polyomavirus MT antigen transformation ability.J Cell Biochem. 2003 Oct 1;90(2):253-66. doi: 10.1002/jcb.10628. J Cell Biochem. 2003. PMID: 14505342
Cited by
-
The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation.J Virol. 2007 Jul;81(13):7069-76. doi: 10.1128/JVI.00115-07. Epub 2007 Apr 18. J Virol. 2007. PMID: 17442716 Free PMC article.
-
Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors.PLoS One. 2009 Sep 7;4(9):e6932. doi: 10.1371/journal.pone.0006932. PLoS One. 2009. PMID: 19812721 Free PMC article.
-
A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis.Mol Cell Biol. 2009 Jan;29(2):402-13. doi: 10.1128/MCB.01035-08. Epub 2008 Nov 17. Mol Cell Biol. 2009. PMID: 19015244 Free PMC article.
-
Oncoprotein GT198 vaccination delays tumor growth in MMTV-PyMT mice.Cancer Lett. 2020 Apr 28;476:57-66. doi: 10.1016/j.canlet.2020.02.005. Epub 2020 Feb 12. Cancer Lett. 2020. PMID: 32061755 Free PMC article.
-
MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists.Nat Commun. 2017 Oct 19;8(1):1036. doi: 10.1038/s41467-017-01059-5. Nat Commun. 2017. PMID: 29051494 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
