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. 2002 Dec;58(Pt 12):2082-6.
doi: 10.1107/s0907444902016360. Epub 2002 Nov 23.

Statistical density modification with non-crystallographic symmetry

Thomas C Terwilliger  1
Affiliations

Statistical density modification with non-crystallographic symmetry

Thomas C Terwilliger. Acta Crystallogr D Biol Crystallogr. 2002 Dec.

Abstract

Statistical density modification is a technique for phase improvement through a calculation of the posterior probability of the phases, given experimental phase information and expectations about features of the electron-density map. The technique can take advantage of both estimates of electron density in the map and uncertainties or probability distributions for those estimates. For crystals with non-crystallographic symmetry (NCS), this allows the use of the expected similarity of electron density at NCS-related points without requiring an implicit assumption that these regions are identical.

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Figures

Figure 1
Figure 1
Effect of scale factor multiplying NCS variance estimates on correlation to model map and on NCS correlation.
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References

    1. Abrahams, J. P. & Leslie, A. G. W. (1996). Acta Cryst. D52, 30–42. - PubMed
    1. Bricogne, G. (1974). Acta Cryst. A30, 395–405.
    1. Chen, C. C. H., Kim, A., Zhang, H., Howard, A. J., Sheldrick, G. M., Dunaway-Mariano, D. & Herzberg, O. (2000). Am. Crystallogr. Assoc. Annu. Meet., Abstract 02.06.03.
    1. Cowtan, K. (1998). Acta Cryst. D54, 750–756. - PubMed
    1. Huber, A. H., Nelson, W. J. & Weis, W. I (1997). Cell, 90, 871–882. - PubMed

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