doi: 10.1016/s1097-2765(02)00702-5.
Histone acetylation regulates the time of replication origin firing
Affiliations
- PMID: 12453428
- DOI: 10.1016/s1097-2765(02)00702-5
Item in Clipboard
Histone acetylation regulates the time of replication origin firing
Mol Cell.
2002 Nov.
Free article
Abstract
The temporal firing of replication origins throughout S phase in yeast depends on unknown determinants within the adjacent chromosomal environment. We demonstrate here that the state of histone acetylation of surrounding chromatin is an important regulator of temporal firing. Deletion of RPD3 histone deacetylase causes earlier origin firing and concurrent binding of the replication factor Cdc45p to origins. In addition, increased acetylation of histones in the vicinity of the late origin ARS1412 by recruitment of the histone acetyltransferase Gcn5p causes ARS1412 alone to fire earlier. These data indicate that histone acetylation is a direct determinant of the timing of origin firing.
Similar articles
-
H3 k36 methylation helps determine the timing of cdc45 association with replication origins.PLoS One. 2009 Jun 12;4(6):e5882. doi: 10.1371/journal.pone.0005882. PLoS One. 2009. PMID: 19521516 Free PMC article.
-
Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase.BMC Mol Biol. 2008 Nov 6;9:100. doi: 10.1186/1471-2199-9-100. BMC Mol Biol. 2008. PMID: 18990212 Free PMC article.
-
Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase.Mol Cell Biol. 2000 May;20(9):3086-96. doi: 10.1128/MCB.20.9.3086-3096.2000. Mol Cell Biol. 2000. PMID: 10757793 Free PMC article.
-
Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage.Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):31-8. doi: 10.1098/rstb.2003.1362. Philos Trans R Soc Lond B Biol Sci. 2004. PMID: 15065654 Free PMC article. Review.
-
The activities of eukaryotic replication origins in chromatin.Biochim Biophys Acta. 2004 Mar 15;1677(1-3):142-57. doi: 10.1016/j.bbaexp.2003.11.015. Biochim Biophys Acta. 2004. PMID: 15020055 Review.
Cited by
-
Rif1 regulates the replication timing domains on the human genome.EMBO J. 2012 Sep 12;31(18):3667-77. doi: 10.1038/emboj.2012.180. Epub 2012 Jul 31. EMBO J. 2012. PMID: 22850674 Free PMC article.
-
Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts.Nucleic Acids Res. 2013 Sep;41(16):7725-37. doi: 10.1093/nar/gkt549. Epub 2013 Jun 20. Nucleic Acids Res. 2013. PMID: 23788677 Free PMC article.
-
Positive and Negative Regulation of DNA Replication Initiation.Trends Genet. 2020 Nov;36(11):868-879. doi: 10.1016/j.tig.2020.06.020. Epub 2020 Jul 29. Trends Genet. 2020. PMID: 32739030 Free PMC article. Review.
-
Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p.BMC Biol. 2007 Sep 19;5:38. doi: 10.1186/1741-7007-5-38. BMC Biol. 2007. PMID: 17880717 Free PMC article.
-
Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states.Mol Biol Cell. 2005 Jun;16(6):2872-81. doi: 10.1091/mbc.e04-11-0997. Epub 2005 Mar 23. Mol Biol Cell. 2005. PMID: 15788566 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
