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. 2002 Nov 15;13(16):2071-4.
doi: 10.1097/00001756-200211150-00016.

Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist

Silvia Zucchini  1 , Andrea Buzzi, Marco Bergamaschi, Claudio Pietra, Gino Villetti, Michele Simonato
Affiliations

Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist

Silvia Zucchini et al. Neuroreport. .

Abstract

The aim of this study was to evaluate the neuroprotective effect of CHF3381, a novel putative NMDA antagonist characterized by a good therapeutic index. We have compared the effects of CHF3381 on kainate seizure-induced neurodegeneration with those produced by the non competitive NMDA receptor antagonist MK-801 and by the Na channel blocker lamotrigine. All compounds have been employed at doses incapable of preventing or attenuating seizures. The fluorescent marker Fluoro-Jade B has been used to identify degenerating cells. Animals pretreated with lamotrigine presented the same degree of cell damage as the controls. As for the controls, a clear correlation was also observed between seizure severity and neurodegeneration. In contrast, MK-801 and CHF3381 completely prevented cell damage. These data indicate that CHF3381 may be successfully utilized in neurological disorders characterized by or associated with neurodegenerative excitotoxicity.

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