Reactivation of ocular dominance plasticity in the adult visual cortex
- PMID: 12424383
- DOI: 10.1126/science.1072699
Reactivation of ocular dominance plasticity in the adult visual cortex
Abstract
In young animals, monocular deprivation leads to an ocular dominance shift, whereas in adults after the critical period there is no such shift. Chondroitin sulphate proteoglycans (CSPGs) are components of the extracellular matrix (ECM) inhibitory for axonal sprouting. We tested whether the developmental maturation of the ECM is inhibitory for experience-dependent plasticity in the visual cortex. The organization of CSPGs into perineuronal nets coincided with the end of the critical period and was delayed by dark rearing. After CSPG degradation with chondroitinase-ABC in adult rats, monocular deprivation caused an ocular dominance shift toward the nondeprived eye. The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity.
Comment in
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Neuroscience. Freeing the bain from the perineuronal net.Science. 2002 Nov 8;298(5596):1187-9. doi: 10.1126/science.1079224. Science. 2002. PMID: 12424361 No abstract available.
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