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. 2002 Nov 2;360(9343):1393-4.
doi: 10.1016/S0140-6736(02)11391-2.

Metapneumovirus and acute wheezing in children

Tuomas Jartti  1 , Bernadette van den Hoogen, Roberto P Garofalo, Albert D M E Osterhaus, Olli Ruuskanen
Affiliations

Metapneumovirus and acute wheezing in children

Tuomas Jartti et al. Lancet. .

Abstract

A new respiratory virus, human metapneumovirus, was recently identified. We detected this virus by PCR in ten (8%) of 132 consecutive children admitted to Turku Hospital, Finland, for acute expiratory wheezing (median age 7 months, range 4-25). The mean duration of hospital stay was 2.5 days (SD 1.6) and mean duration of respiratory symptoms was 19 days (8). The white blood cell count, C-reactive protein, and regulated upon activation, normal T-cell-expressed and T-cell-secreted (RANTES) concentrations in nasal secretion remained low, whereas interleukin 8 concentrations in nasal secretion were high. Human metapneumovirus is a clinically important causative agent of acute wheezing in young children.

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