Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jan-Feb;23(1):2-7.
doi: 10.1159/000066303.

Hyperuricemia causes glomerular hypertrophy in the rat

Takahiko Nakagawa  1 , Marilda Mazzali, Duk-Hee Kang, John Kanellis, Susumu Watanabe, Laura G Sanchez-Lozada, Bernardo Rodriguez-Iturbe, Jaime Herrera-Acosta, Richard J Johnson
Affiliations

Hyperuricemia causes glomerular hypertrophy in the rat

Takahiko Nakagawa et al. Am J Nephrol. 2003 Jan-Feb.

Abstract

Background/aims: Rats with mild hyperuricemia develop systemic hypertension, interstitial renal disease, afferent arteriolopathy, and increased renin expression [Mazzali et al.: Am J Physiol 2002;6:F991-F997]. We hypothesized that hyperuricemia might also induce glomerular changes.

Methods: We reviewed renal biopsies of rats previously made hyperuricemic for 7 weeks with the uricase inhibitor, oxonic acid. Controls included normal rats and oxonic acid-treated rats administered allopurinol, benziodarone, hydrochlorothiazide, or enalapril. Glomeruli were examined for size (computer image analysis) and structure (histology). An additional group of rats were administered oxonic acid or control diet for 6 months.

Results: Renal biopsies showed that hyperuricemic rats had a 30% increase in glomerular tuft area (p < 0.01); these changes were prevented by allopurinol and benziodarone. Control of blood pressure with hydrochlorothiazide did not prevent the development of glomerular hypertrophy, whereas enalapril partially reduced the glomerular hypertrophy. Prolonged hyperuricemia was associated with the development of microalbuminuria (p < 0.05) and glomerulosclerosis (22 vs. 10%, p < 0.05) compared to control rats.

Conclusions: Hyperuricemic rats develop glomerular hypertrophy that can be prevented in part by ACE inhibitor therapy. Prolonged hyperuricemia is associated with the development of glomerulosclerosis in the rat.

PubMed Disclaimer

Similar articles

  • Mild hyperuricemia induces glomerular hypertension in normal rats.
    Sánchez-Lozada LG, Tapia E, Avila-Casado C, Soto V, Franco M, Santamaría J, Nakagawa T, Rodríguez-Iturbe B, Johnson RJ, Herrera-Acosta J. Sánchez-Lozada LG, et al. Am J Physiol Renal Physiol. 2002 Nov;283(5):F1105-10. doi: 10.1152/ajprenal.00170.2002. Am J Physiol Renal Physiol. 2002. PMID: 12372787
  • Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats.
    Sánchez-Lozada LG, Tapia E, Santamaría J, Avila-Casado C, Soto V, Nepomuceno T, Rodríguez-Iturbe B, Johnson RJ, Herrera-Acosta J. Sánchez-Lozada LG, et al. Kidney Int. 2005 Jan;67(1):237-47. doi: 10.1111/j.1523-1755.2005.00074.x. Kidney Int. 2005. PMID: 15610247
  • A role for uric acid in the progression of renal disease.
    Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, Truong L, Harris R, Johnson RJ. Kang DH, et al. J Am Soc Nephrol. 2002 Dec;13(12):2888-97. doi: 10.1097/01.asn.0000034910.58454.fd. J Am Soc Nephrol. 2002. PMID: 12444207
  • Hemodynamics of hyperuricemia.
    Sánchez-Lozada LG, Tapia E, Rodríguez-Iturbe B, Johnson RJ, Herrera-Acosta J. Sánchez-Lozada LG, et al. Semin Nephrol. 2005 Jan;25(1):19-24. doi: 10.1016/j.semnephrol.2004.09.004. Semin Nephrol. 2005. PMID: 15660330 Review.
  • Uric acid--a uremic toxin?
    Nakagawa T, Mazzali M, Kang DH, Sánchez-Lozada LG, Herrera-Acosta J, Johnson RJ. Nakagawa T, et al. Blood Purif. 2006;24(1):67-70. doi: 10.1159/000089440. Blood Purif. 2006. PMID: 16361844 Review.
See all similar articles

Cited by

See all "Cited by" articles

Publication types