Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
- PMID: 12368865
- DOI: 10.1038/nature01099
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
Abstract
Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. A synteny map of 2,212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. Of about 5,300 P. falciparum genes, more than 3,300 P. y. yoelii orthologues of predominantly metabolic function were identified. Over 800 copies of a variant antigen gene located in subtelomeric regions were found. This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.
Comment in
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Integrated programme is key to malaria control.Nature. 2002 Oct 3;419(6906):431. doi: 10.1038/419431a. Nature. 2002. PMID: 12368831 No abstract available.
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The grand assault.Nature. 2002 Oct 3;419(6906):493-4. doi: 10.1038/419493a. Nature. 2002. PMID: 12368861 No abstract available.
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Biological revelations.Nature. 2002 Oct 3;419(6906):495-6. doi: 10.1038/419495a. Nature. 2002. PMID: 12368862 No abstract available.
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