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. 2002 Oct 18;298(5593):580-4.
doi: 10.1126/science.1076996. Epub 2002 Sep 26.

Microfluidic large-scale integration

Todd Thorsen  1 , Sebastian J Maerkl, Stephen R Quake
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Microfluidic large-scale integration

Todd Thorsen et al. Science. .
Free article

Abstract

We developed high-density microfluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large-scale integration. A key component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. We used these integrated microfluidic networks to construct the microfluidic analog of a comparator array and a microfluidic memory storage device whose behavior resembles random-access memory.

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