Influence of antibody-mediated immune suppression on clinical, viral, and immune responses to swine influenza infection
- PMID: 123140
Influence of antibody-mediated immune suppression on clinical, viral, and immune responses to swine influenza infection
Abstract
Antibody-mediated immune suppression occurred when newborn pigs with naturally acquired passive antibody were exposed to seine influenza virus. Frequency and relative ease of recovery of virus from nasal secretions were inversely related to the concentration of specific passive antibody existing at time of exposure. Severe overt respiratory signs during the acute stages of the disease were observed only in pigs with low passive antibody concentrations. The concentration of passive antibody at the time of exposure determined the immune status of the pig during the convalescent stage of disease. Infection could occur in the presence of high passive antibody concentrations, but the pig was not immunologically stimulated. Reexposure after the decay of passive antibody produced primary immune respone, severe clinical reinfection, and recovery of virus from nasal secretions for a period of time similar to that seen in pigs having their first exposure. Infection of newborn pigs with low passive antibody concentrations led to immunologic priming. A second exposure to virus produced a secondary immune response, mild clinical disease, and shortened time during which virus was recovered from nasal secretions. The relevance of these studies for the practice of vaccination or infections of the dam before parturition so that the neonate will have specific passive immunity is discussed.
Similar articles
-
Assessment of resistance to influenza virus infection in animal models.Dev Biol Stand. 1975;28:307-18. Dev Biol Stand. 1975. PMID: 1126574
-
The immune response and maternal antibody interference to a heterologous H1N1 swine influenza virus infection following vaccination.Vet Immunol Immunopathol. 2006 Aug 15;112(3-4):117-28. doi: 10.1016/j.vetimm.2006.02.008. Epub 2006 Apr 18. Vet Immunol Immunopathol. 2006. PMID: 16621020
-
Overcoming maternal antibody interference by vaccination with human adenovirus 5 recombinant viruses expressing the hemagglutinin and the nucleoprotein of swine influenza virus.Vet Microbiol. 2006 Nov 26;118(1-2):67-75. doi: 10.1016/j.vetmic.2006.07.014. Epub 2006 Jul 25. Vet Microbiol. 2006. PMID: 16939702
-
Genetic relationships, serological cross-reaction and cross-protection between H1N2 and other influenza A virus subtypes endemic in European pigs.Virus Res. 2004 Jul;103(1-2):115-24. doi: 10.1016/j.virusres.2004.02.023. Virus Res. 2004. PMID: 15163499
-
Antigens (and recombinants) and immune response to avian influenza.Am J Vet Res. 1975 Apr;36(4 Pt 2):503-4. Am J Vet Res. 1975. PMID: 1092217 Review. No abstract available.
Cited by
-
Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination.PLoS One. 2019 Nov 14;14(11):e0224854. doi: 10.1371/journal.pone.0224854. eCollection 2019. PLoS One. 2019. PMID: 31725751 Free PMC article.
-
Optimal Use of Vaccines for Control of Influenza A Virus in Swine.Vaccines (Basel). 2015 Jan 30;3(1):22-73. doi: 10.3390/vaccines3010022. Vaccines (Basel). 2015. PMID: 26344946 Free PMC article. Review.
-
Effect of strain-specific maternally-derived antibodies on influenza A virus infection dynamics in nursery pigs.PLoS One. 2019 Jan 14;14(1):e0210700. doi: 10.1371/journal.pone.0210700. eCollection 2019. PLoS One. 2019. PMID: 30640929 Free PMC article.
-
Does Vaccine-Induced Maternally-Derived Immunity Protect Swine Offspring against Influenza a Viruses? A Systematic Review and Meta-Analysis of Challenge Trials from 1990 to May 2021.Animals (Basel). 2023 Oct 3;13(19):3085. doi: 10.3390/ani13193085. Animals (Basel). 2023. PMID: 37835692 Free PMC article. Review.
-
Transmission dynamics of pandemic influenza A(H1N1)pdm09 virus in humans and swine in backyard farms in Tumbes, Peru.Influenza Other Respir Viruses. 2016 Jan;10(1):47-56. doi: 10.1111/irv.12329. Influenza Other Respir Viruses. 2016. PMID: 26011186 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources