Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
- PMID: 12210791
- DOI: 10.1002/ana.10279
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
Abstract
Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.
Similar articles
-
Neuropathological spectrum of synucleinopathies.Mov Disord. 2003 Sep;18 Suppl 6:S2-12. doi: 10.1002/mds.10557. Mov Disord. 2003. PMID: 14502650 Review.
-
Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology.Parkinsonism Relat Disord. 2007;13 Suppl 3:S221-4. doi: 10.1016/S1353-8020(08)70005-1. Parkinsonism Relat Disord. 2007. PMID: 18267239
-
A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease.Ann Neurol. 2005 Mar;57(3):429-34. doi: 10.1002/ana.20393. Ann Neurol. 2005. PMID: 15732120
-
In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.Eur J Pharmacol. 2009 Sep 1;617(1-3):54-8. doi: 10.1016/j.ejphar.2009.06.042. Epub 2009 Jul 1. Eur J Pharmacol. 2009. PMID: 19576880
-
Alpha-synuclein, Abeta and Alzheimer's disease.Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):103-8. doi: 10.1016/S0278-5846(02)00339-1. Prog Neuropsychopharmacol Biol Psychiatry. 2003. PMID: 12551731 Review.
Cited by
-
Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype.Arch Neurol. 2006 Mar;63(3):370-6. doi: 10.1001/archneur.63.3.370. Arch Neurol. 2006. PMID: 16533963 Free PMC article.
-
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.Ann Neurol. 2019 Feb;85(2):259-271. doi: 10.1002/ana.25392. Epub 2019 Jan 7. Ann Neurol. 2019. PMID: 30549331 Free PMC article.
-
Misfolded, protease-resistant proteins in animal models and human neurodegenerative disease.J Clin Invest. 2002 Nov;110(10):1403-5. doi: 10.1172/JCI17164. J Clin Invest. 2002. PMID: 12438436 Free PMC article. Review. No abstract available.
-
Early-onset dementia with Lewy bodies.Brain Pathol. 2004 Apr;14(2):137-47. doi: 10.1111/j.1750-3639.2004.tb00046.x. Brain Pathol. 2004. PMID: 15193026 Free PMC article.
-
A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation.J Neurochem. 2010 Apr;113(2):374-88. doi: 10.1111/j.1471-4159.2010.06592.x. Epub 2010 Feb 2. J Neurochem. 2010. PMID: 20132485 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous