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. 2002 Aug;52(2):205-10.
doi: 10.1002/ana.10279.

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

John E Duda  1 , Benoit I Giasson, Meghann E Mabon, Virginia M-Y Lee, John Q Trojanowski
Affiliations

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

John E Duda et al. Ann Neurol. 2002 Aug.

Abstract

Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.

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