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Review
. 2002 Sep;3(9):651-62.
doi: 10.1038/nrm909.

Stats: transcriptional control and biological impact

David E Levy  1 , J E Darnell Jr
Affiliations
Review

Stats: transcriptional control and biological impact

David E Levy et al. Nat Rev Mol Cell Biol. 2002 Sep.

Abstract

Extracellular proteins bound to cell-surface receptors can change nuclear gene expression patterns in minutes, with far-reaching consequences for development, cell growth and homeostasis. The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the study of these proteins an important topic of current research.

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