Review
doi: 10.1016/s0959-437x(02)00334-9.
Intramembrane proteolysis controls diverse signalling pathways throughout evolution
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- PMID: 12200155
- DOI: 10.1016/s0959-437x(02)00334-9
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Review
Intramembrane proteolysis controls diverse signalling pathways throughout evolution
Curr Opin Genet Dev.
2002 Oct.
Abstract
Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.
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