Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
- PMID: 12195436
- DOI: 10.1038/nm757
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
Erratum in
- Nat Med. 2012 Oct;18(10):1592
Abstract
The H5N1 influenza viruses transmitted to humans in 1997 were highly virulent, but the mechanism of their virulence in humans is largely unknown. Here we show that lethal H5N1 influenza viruses, unlike other human, avian and swine influenza viruses, are resistant to the antiviral effects of interferons and tumor necrosis factor alpha. The nonstructural (NS) gene of H5N1 viruses is associated with this resistance. Pigs infected with recombinant human H1N1 influenza virus that carried the H5N1 NS gene experienced significantly greater and more prolonged viremia, fever and weight loss than did pigs infected with wild-type human H1N1 influenza virus. These effects required the presence of glutamic acid at position 92 of the NS1 molecule. These findings may explain the mechanism of the high virulence of H5N1 influenza viruses in humans.
Comment in
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Freedom of information.Nat Med. 2002 Sep;8(9):899. doi: 10.1038/nm0902-899. Nat Med. 2002. PMID: 12205431 No abstract available.
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The makings of a killer.Nat Med. 2002 Sep;8(9):927-8. doi: 10.1038/nm0902-927. Nat Med. 2002. PMID: 12205448 No abstract available.
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Lethal H5N1 influenza viruses are not resistant to interferon action in human, simian, porcine or chicken cells.Nat Med. 2012 Oct;18(10):1456-7. doi: 10.1038/nm.2879. Nat Med. 2012. PMID: 23042343 No abstract available.
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