doi: 10.1006/jtbi.2002.2550.
A mathematical model for the germinal center morphology and affinity maturation
Affiliations
- PMID: 12183119
- DOI: 10.1006/jtbi.2002.2550
Item in Clipboard
A mathematical model for the germinal center morphology and affinity maturation
J Theor Biol.
.
Free article
Abstract
During germinal center reactions, the appearance of two specific zones are observed: the dark and the light zone. Up to now, the origin and function of these zones are poorly understood. In the framework of a stochastic and discrete model, several possible pathways of zone development during germinal center reactions are investigated. The importance of the zones in the germinal center for affinity maturation, i.e. the process of antibody optimization is discussed.
Similar articles
-
Stochastic discrete event simulation of germinal center reactions.Phys Rev E Stat Nonlin Soft Matter Phys. 2005 May;71(5 Pt 1):051907. doi: 10.1103/PhysRevE.71.051907. Epub 2005 May 24. Phys Rev E Stat Nonlin Soft Matter Phys. 2005. PMID: 16089571
-
Dynamics of one-pass germinal center models: implications for affinity maturation.Bull Math Biol. 2000 Jan;62(1):121-53. doi: 10.1006/bulm.1999.0144. Bull Math Biol. 2000. PMID: 10824424
-
Conclusions from two model concepts on germinal center dynamics and morphology.Dev Immunol. 2002 Dec;9(4):203-14. doi: 10.1080/1044-6670310001597060. Dev Immunol. 2002. PMID: 15144017 Free PMC article.
-
Germinal centres seen through the mathematical eye: B-cell models on the catwalk.Trends Immunol. 2009 Apr;30(4):157-64. doi: 10.1016/j.it.2009.01.005. Epub 2009 Mar 11. Trends Immunol. 2009. PMID: 19282244 Review.
-
Germinal centre cell kinetics.J Pathol. 1998 Jul;185(3):229-33. doi: 10.1002/(SICI)1096-9896(199807)185:3<229::AID-PATH86>3.0.CO;2-L. J Pathol. 1998. PMID: 9771474 Review.
Cited by
-
A one-shot germinal center model under protein structural stability constraints.Phys Biol. 2013 Apr;10(2):025001. doi: 10.1088/1478-3975/10/2/025001. Epub 2013 Mar 15. Phys Biol. 2013. PMID: 23492682 Free PMC article.
-
Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment.Processes (Basel). 2019 Jan;7(1):37. doi: 10.3390/pr7010037. Epub 2019 Jan 13. Processes (Basel). 2019. PMID: 30701168 Free PMC article.
-
A review of quantitative modeling of B cell responses to antigenic challenge.J Pharmacokinet Pharmacodyn. 2014 Oct;41(5):445-59. doi: 10.1007/s10928-014-9388-7. Epub 2014 Oct 19. J Pharmacokinet Pharmacodyn. 2014. PMID: 25326873 Review.
-
Cellular choreography in the germinal center: new visions from in vivo imaging.Semin Immunopathol. 2010 Sep;32(3):239-55. doi: 10.1007/s00281-010-0214-z. Epub 2010 Jul 9. Semin Immunopathol. 2010. PMID: 20614218 Free PMC article. Review.
-
A Network Model to Describe the Terminal Differentiation of B Cells.PLoS Comput Biol. 2016 Jan 11;12(1):e1004696. doi: 10.1371/journal.pcbi.1004696. eCollection 2016 Jan. PLoS Comput Biol. 2016. PMID: 26751566 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
