Oxidation of biological thiols by highly reactive disulfide-S-oxides
Affiliations
- PMID: 12168727
Item in Clipboard
Oxidation of biological thiols by highly reactive disulfide-S-oxides
Gen Physiol Biophys.
2002 Mar.
Free article
Abstract
Oxidative stress involves the generation of a number of reactive species, among them 'reactive oxygen species' and 'reactive nitrogen species'. Recent reports have indicated that disulfide-S-monoxides (thiosulfinates) and disulfide-S-dioxides (thiosulfonates) are formed under conditions of oxidative stress. We have now been able to demonstrate that these species are highly reactive and rapidly oxidise thiols. Glutathione and cysteine were oxidised to mixed disulfides by the action of disulfide-S-oxides. Oxidative attack on the zinc/sulfur protein metallothionein with concomitant zinc release was readily accomplished by these 'reactive sulfur species' whereas hydrogen peroxide showed minimal zinc release.
Similar articles
-
Reactive sulfur species: an emerging concept in oxidative stress.Biol Chem. 2002 Mar-Apr;383(3-4):375-88. doi: 10.1515/BC.2002.042. Biol Chem. 2002. PMID: 12033429 Review.
-
Interactions between reactive oxygen species and sulfhydryl groups of cysteine, acetylcysteine and glutathione.Pol J Pharmacol. 1995 Jan-Feb;47(1):59-62. Pol J Pharmacol. 1995. PMID: 7550550
-
Reactive sulphur species in oxidative signal transduction.Biochem Soc Trans. 2004 Dec;32(Pt 6):1015-7. doi: 10.1042/BST0321015. Biochem Soc Trans. 2004. PMID: 15506951
-
Reactive sulphur species: an in vitro investigation of the oxidation properties of disulphide S-oxides.Biochem J. 2002 Jun 1;364(Pt 2):579-85. doi: 10.1042/BJ20011882. Biochem J. 2002. PMID: 12023902 Free PMC article.
-
Thiolation and nitrosation of cysteines in biological fluids and cells.Amino Acids. 2003 Dec;25(3-4):323-39. doi: 10.1007/s00726-003-0020-1. Epub 2003 Aug 21. Amino Acids. 2003. PMID: 14661094 Review.
Cited by
-
The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein.Nat Commun. 2014;5:2958. doi: 10.1038/ncomms3958. Nat Commun. 2014. PMID: 24389582 Free PMC article.
-
Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice.Am J Pathol. 2004 Jun;164(6):1959-66. doi: 10.1016/S0002-9440(10)63756-X. Am J Pathol. 2004. PMID: 15161632 Free PMC article.
-
Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia/reperfusion.Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5987-91. doi: 10.1073/pnas.0501519102. Epub 2005 Apr 19. Proc Natl Acad Sci U S A. 2005. PMID: 15840721 Free PMC article.
-
Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms.Acta Pharmacol Sin. 2014 Dec;35(12):1527-36. doi: 10.1038/aps.2014.119. Epub 2014 Nov 24. Acta Pharmacol Sin. 2014. PMID: 25418378 Free PMC article.
-
Impairment of mitochondrial acetoacetyl CoA thiolase activity in the colonic mucosa of patients with ulcerative colitis.Gut. 2007 Nov;56(11):1543-9. doi: 10.1136/gut.2006.108449. Epub 2007 May 4. Gut. 2007. PMID: 17483192 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
