Review
doi: 10.1038/nrm883.
Signal transduction and endocytosis: close encounters of many kinds
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- PMID: 12154371
- DOI: 10.1038/nrm883
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Review
Signal transduction and endocytosis: close encounters of many kinds
Nat Rev Mol Cell Biol.
2002 Aug.
Abstract
Binding of hormones, growth factors and other cell modulators to cell-surface receptors triggers a complex array of signal-transduction events. The activation of many receptors also accelerates their endocytosis. Endocytic transport is important in regulating signal transduction and in mediating the formation of specialized signalling complexes. Conversely, signal-transduction events modulate specific components of the endocytic machinery. Recent studies of protein tyrosine kinases and G-protein-coupled receptors have shed new light on the mechanisms and functional consequences of this bidirectional interplay between signalling and membrane-transport networks.
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