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. 2002 Oct 4;277(40):37487-91.
doi: 10.1074/jbc.M206083200. Epub 2002 Jul 22.

Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis

Morihiro Matsuda  1 , Iichiro Shimomura, Masataka Sata, Yukio Arita, Makoto Nishida, Norikazu Maeda, Masahiro Kumada, Yoshihisa Okamoto, Hiroyuki Nagaretani, Hitoshi Nishizawa, Ken Kishida, Ryutaro Komuro, Noriyuki Ouchi, Shinji Kihara, Ryozo Nagai, Tohru Funahashi, Yuji Matsuzawa
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Free article

Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis

Morihiro Matsuda et al. J Biol Chem. .
Free article

Abstract

Obesity is more linked to vascular disease, including atherosclerosis and restenotic change, after balloon angioplasty. The precise mechanism linking obesity and vascular disease is still unclear. Previously we have demonstrated that the plasma levels of adiponectin, an adipose-derived hormone, decreases in obese subjects, and that hypoadiponectinemia is associated to ischemic heart disease. In current the study, we investigated the in vivo role of adiponectin on the neointimal thickening after artery injury using adiponectin-deficient mice and adiponectin-producing adenovirus. Adiponectin-deficient mice showed severe neointimal thickening and increased proliferation of vascular smooth muscle cells in mechanically injured arteries. Adenovirus-mediated supplement of adiponectin attenuated neointimal proliferation. In cultured smooth muscle cells, adiponectin attenuated DNA synthesis induced by growth factors including platelet-derived growth factor, heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), basic fibroblast growth factor, and EGF and cell proliferation and migration induced by HB-EGF. In cultured endothelial cells, adiponectin attenuated HB-EGF expression stimulated by tumor necrosis factor alpha. The current study suggests an adipo-vascular axis, a direct link between fat and artery. A therapeutic strategy to increase plasma adiponectin should be useful in preventing vascular restenosis after angioplasty.

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