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. 2002 Aug 9;297(5583):1031-4.
doi: 10.1126/science.1073560. Epub 2002 Jul 18.

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

Klaus Okkenhaug  1 , Antonio Bilancio, Géraldine Farjot, Helen Priddle, Sara Sancho, Emma Peskett, Wayne Pearce, Stephen E Meek, Ashreena Salpekar, Michael D Waterfield, Andrew J H Smith, Bart Vanhaesebroeck
Affiliations

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

Klaus Okkenhaug et al. Science. .

Abstract

Class IA phosphoinositide 3-kinases (PI3Ks) are a family of p85/p110 heterodimeric lipid kinases that generate second messenger signals downstream of tyrosine kinases, thereby controlling cell metabolism, growth, proliferation, differentiation, motility, and survival. Mammals express three class IA catalytic subunits: p110alpha, p110beta, and p110delta. It is unclear to what extent these p110 isoforms have overlapping or distinct biological roles. Mice expressing a catalytically inactive form of p110delta (p110delta(D910A)) were generated by gene targeting. Antigen receptor signaling in B and T cells was impaired and immune responses in vivo were attenuated in p110delta mutant mice. They also developed inflammatory bowel disease. These results reveal a selective role for p110delta in immunity.

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