Review
doi: 10.1016/s0166-2236(02)02199-9.
Retrograde signaling by the neurotrophins follows a well-worn trk
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- PMID: 12127743
- DOI: 10.1016/s0166-2236(02)02199-9
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Review
Retrograde signaling by the neurotrophins follows a well-worn trk
Trends Neurosci.
2002 Aug.
Abstract
The mechanism that allows a neuron to send cues received at its terminal to its cell body and nucleus has proved elusive. However, a recent study by Howe and colleagues indicates that neurotrophin signaling via the trkA receptor requires formation of a signaling endosome containing NGF and trkA. Thus, endocytosis of the neurotrophin-receptor complex is a crucial step in the generation of intracellular signaling platforms required for activation and compartmentalization of signaling events.
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