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. 2002 Jul;441(1):47-52.
doi: 10.1007/s00428-001-0567-8. Epub 2001 Nov 24.

Three-dimensional analysis of alveolar structure in usual interstitial pneumonia

Takayuki Honda  1 , Hiroyoshi Ota, Kenichi Arai, Masayoshi Hayama, Keisaku Fujimoto, Yoshitaka Yamazaki, Masayuki Haniuda
Affiliations

Three-dimensional analysis of alveolar structure in usual interstitial pneumonia

Takayuki Honda et al. Virchows Arch. 2002 Jul.

Abstract

The etiology of usual interstitial pneumonia (UIP), a progressive lung disease, remains unclear. We examined alveolar structure in UIP three-dimensionally. Lung biopsy specimens from five patients with idiopathic pulmonary fibrosis were used. Sections 150-microm thick were stained with elastica solution for elastic fibers, with alpha-smooth muscle actin antibody for myofibroblasts, with anti-Thomsen-Friedenreich antibody for type-II pneumocytes and with anti-CD34 antibody for blood vessels. We examined them three-dimensionally using a laser confocal microscope or light microscope. In the fibrotic lesions, the thick elastic fibers forming the alveolar framework were not particularly dense considering the reduction in alveolar volume. Near the fibrotic lesions, some of the thin elastic fibers in the alveolar wall were slightly sinuous and ended with rounded tips. Type-II pneumocytes had proliferated and were distributed uniformly over the alveolar surface. Smooth muscle actin filaments were detected only around the alveolar orifice. These findings show that in UIP destruction of the elastic fiber framework of the alveoli may lead to irreversible focal alveolar collapse after damage to the alveolar epithelial cells, and proliferation of type-II pneumocytes may be involved with this elastolysis.

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