Review
doi: 10.1038/nrm859.
Opinion: Building epithelial architecture: insights from three-dimensional culture models
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- PMID: 12094219
- DOI: 10.1038/nrm859
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Review
Opinion: Building epithelial architecture: insights from three-dimensional culture models
Nat Rev Mol Cell Biol.
2002 Jul.
Abstract
How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.
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