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. 2002 Jun 13;417(6890):763-7.
doi: 10.1038/nature00815.

Regulation of Arabidopsis cryptochrome 2 by blue-light-dependent phosphorylation

Dror Shalitin  1 , Hongyun Yang, Todd C Mockler, Maskit Maymon, Hongwei Guo, Garry C Whitelam, Chentao Lin
Affiliations

Regulation of Arabidopsis cryptochrome 2 by blue-light-dependent phosphorylation

Dror Shalitin et al. Nature. .

Erratum in

  • Nature 2002 Jul 25;418(6896):447

Abstract

Cryptochromes are blue/ultraviolet-A light receptors that mediate various light responses in plants and animals. But the initial photochemical reaction of cryptochrome is still unclear. For example, although most photoreceptors are known to undergo light-dependent protein modification such as phosphorylation, no blue-light dependent phosphorylation has been reported for a cryptochrome. Arabidopsis cryptochrome 2 (cry2) mediates light regulation of seedling development and photoperiodic flowering. The physiological activity and cellular level of cry2 protein are light-dependent, and protein protein interactions are important for cry2 function. Here we report that cry2 undergoes a blue-light-dependent phosphorylation, and that cry2 phosphorylation is associated with its function and regulation. Our results suggest that, in the absence of light, cry2 remains unphosphorylated, inactive and stable; absorption of blue light induces the phosphorylation of cry2, triggering photomorphogenic responses and eventually degradation of the photoreceptor.

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