A high-resolution recombination map of the human genome
- PMID: 12053178
- DOI: 10.1038/ng917
A high-resolution recombination map of the human genome
Abstract
Determination of recombination rates across the human genome has been constrained by the limited resolution and accuracy of existing genetic maps and the draft genome sequence. We have genotyped 5,136 microsatellite markers for 146 families, with a total of 1,257 meiotic events, to build a high-resolution genetic map meant to: (i) improve the genetic order of polymorphic markers; (ii) improve the precision of estimates of genetic distances; (iii) correct portions of the sequence assembly and SNP map of the human genome; and (iv) build a map of recombination rates. Recombination rates are significantly correlated with both cytogenetic structures (staining intensity of G bands) and sequence (GC content, CpG motifs and poly(A)/poly(T) stretches). Maternal and paternal chromosomes show many differences in locations of recombination maxima. We detected systematic differences in recombination rates between mothers and between gametes from the same mother, suggesting that there is some underlying component determined by both genetic and environmental factors that affects maternal recombination rates.
Comment in
-
The Iceland map.Nat Genet. 2002 Jul;31(3):225-6. doi: 10.1038/ng920. Epub 2002 Jun 10. Nat Genet. 2002. PMID: 12053179 No abstract available.
Similar articles
-
Analysis of meiotic recombination in 22q11.2, a region that frequently undergoes deletions and duplications.BMC Med Genet. 2007 Apr 2;8:14. doi: 10.1186/1471-2350-8-14. BMC Med Genet. 2007. PMID: 17397557 Free PMC article.
-
The distribution and causes of meiotic recombination in the human genome.Biochem Soc Trans. 2006 Aug;34(Pt 4):526-30. doi: 10.1042/BST0340526. Biochem Soc Trans. 2006. PMID: 16856851
-
Heterogeneity in rates of recombination in the 6-Mb region telomeric to the human major histocompatibility complex.Genomics. 1997 Jul 15;43(2):226-31. doi: 10.1006/geno.1997.4800. Genomics. 1997. PMID: 9244441
-
Update on the Human Genome Project.Clin Lab Med. 1995 Dec;15(4):973-88. Clin Lab Med. 1995. PMID: 8838234 Review.
-
A genetic linkage map of chromosome 21: a look at meiotic phenomena.Prog Clin Biol Res. 1993;384:51-61. Prog Clin Biol Res. 1993. PMID: 8115407 Review.
Cited by
-
DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes.Nat Commun. 2013;4:1502. doi: 10.1038/ncomms2502. Nat Commun. 2013. PMID: 23422670 Free PMC article.
-
A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).PLoS Genet. 2013;9(1):e1003147. doi: 10.1371/journal.pgen.1003147. Epub 2013 Jan 10. PLoS Genet. 2013. PMID: 23326239 Free PMC article.
-
Sex-specific recombination patterns predict parent of origin for recurrent genomic disorders.BMC Med Genomics. 2021 Jun 9;14(1):154. doi: 10.1186/s12920-021-00999-8. BMC Med Genomics. 2021. PMID: 34107974 Free PMC article.
-
Modeling the effects of consanguinity on autosomal and X-chromosomal runs of homozygosity and identity-by-descent sharing.G3 (Bethesda). 2024 Feb 7;14(2):jkad264. doi: 10.1093/g3journal/jkad264. G3 (Bethesda). 2024. PMID: 37972246 Free PMC article.
-
Autosomal dominant late-onset spinal motor neuronopathy is linked to a new locus on chromosome 22q11.2-q13.2.Eur J Hum Genet. 2012 Nov;20(11):1193-6. doi: 10.1038/ejhg.2012.76. Epub 2012 Apr 25. Eur J Hum Genet. 2012. PMID: 22535186 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
