Review
doi: 10.1002/jcb.10054.
Interleukin 17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis
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- PMID: 12046855
- DOI: 10.1002/jcb.10054
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Review
Interleukin 17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis
J Cell Biochem Suppl.
2002.
Abstract
Interleukin 17 (IL-17) is an essential proinflammatory T-cell derived cytokine with various biological actions. IL-17 was found to have a pivotal role in microbial host defense by interconnecting lymphoid and myeloid host defense. It also acts as a stimulatory hematopoietic cytokine by expanding myeloid progenitors and initiating proliferation of mature neutrophils. This article summarizes results to date on IL-17 research and discusses gene therapy based strategies that were employed to determine its biological functions and significance. A comprehensive working model for IL-17 is introduced.
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