ATP-dependent nucleosome remodeling
- PMID: 12045097
- DOI: 10.1146/annurev.biochem.71.110601.135400
ATP-dependent nucleosome remodeling
Abstract
It has been a long-standing challenge to decipher the principles that enable cells to both organize their genomes into compact chromatin and ensure that the genetic information remains accessible to regulatory factors and enzymes within the confines of the nucleus. The discovery of nucleosome remodeling activities that utilize the energy of ATP to render nucleosomal DNA accessible has been a great leap forward. In vitro, these enzymes weaken the tight wrapping of DNA around the histone octamers, thereby facilitating the sliding of histone octamers to neighboring DNA segments, their displacement to unlinked DNA, and the accumulation of patches of accessible DNA on the surface of nucleosomes. It is presumed that the collective action of these enzymes endows chromatin with dynamic properties that govern all nuclear functions dealing with chromatin as a substrate. The diverse set of ATPases that qualify as the molecular motors of the nucleosome remodeling process have a common history and are part of a superfamily. The physiological context of their remodeling action builds on the association with a wide range of other proteins to form distinct complexes for nucleosome remodeling. This review summarizes the recent progress in our understanding of the mechanisms underlying the nucleosome remodeling reaction, the targeting of remodeling machines to selected sites in chromatin, and their integration into complex regulatory schemes.
Similar articles
-
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.Nature. 1998 Oct 29;395(6705):917-21. doi: 10.1038/27699. Nature. 1998. PMID: 9804427
-
Mi2, an auto-antigen for dermatomyositis, is an ATP-dependent nucleosome remodeling factor.Nucleic Acids Res. 2001 Jun 15;29(12):2517-21. doi: 10.1093/nar/29.12.2517. Nucleic Acids Res. 2001. PMID: 11410659 Free PMC article.
-
The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes.Genes Dev. 2001 Apr 1;15(7):827-32. doi: 10.1101/gad.876201. Genes Dev. 2001. PMID: 11297506 Free PMC article.
-
Chromatin remodeling by ATP-dependent molecular machines.Bioessays. 2003 Dec;25(12):1192-200. doi: 10.1002/bies.10359. Bioessays. 2003. PMID: 14635254 Review.
-
Chromatin remodeling complexes: ATP-dependent machines in action.Biochem Cell Biol. 2005 Aug;83(4):405-17. doi: 10.1139/o05-115. Biochem Cell Biol. 2005. PMID: 16094444 Review.
Cited by
-
Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.Cell. 2013 Jan 17;152(1-2):248-61. doi: 10.1016/j.cell.2012.12.006. Cell. 2013. PMID: 23332759 Free PMC article.
-
Structure and Mechanisms of SF1 DNA Helicases.Adv Exp Med Biol. 2013;767:17-46. doi: 10.1007/978-1-4614-5037-5_2. Adv Exp Med Biol. 2013. PMID: 23161005 Free PMC article.
-
Minireview: applications of next-generation sequencing on studies of nuclear receptor regulation and function.Mol Endocrinol. 2012 Oct;26(10):1651-9. doi: 10.1210/me.2012-1150. Epub 2012 Aug 28. Mol Endocrinol. 2012. PMID: 22930692 Free PMC article. Review.
-
Structural dynamics of nucleosomes at single-molecule resolution.Trends Biochem Sci. 2012 Oct;37(10):425-35. doi: 10.1016/j.tibs.2012.06.006. Epub 2012 Jul 23. Trends Biochem Sci. 2012. PMID: 22831768 Free PMC article. Review.
-
The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions.Mol Cell Biol. 2005 Nov;25(22):9886-96. doi: 10.1128/MCB.25.22.9886-9896.2005. Mol Cell Biol. 2005. PMID: 16260604 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
