Modes of neuronal migration in the developing cerebral cortex
- PMID: 12042877
- DOI: 10.1038/nrn845
Modes of neuronal migration in the developing cerebral cortex
Abstract
The conventional scheme of cortical formation shows that postmitotic neurons migrate away from the germinal ventricular zone to their positions in the developing cortex, guided by the processes of radial glial cells. However, recent studies indicate that different neuronal types adopt distinct modes of migration in the developing cortex. Here, we review evidence for two modes of radial movement: somal translocation, which is adopted by the early-generated neurons; and glia-guided locomotion, which is used predominantly by pyramidal cells. Cortical interneurons, which originate in the ventral telencephalon, use a third mode of migration. They migrate tangentially into the cortex, then seek the ventricular zone before moving radially to take up their positions in the cortical anlage.
Similar articles
-
Control of tangential/non-radial migration of neurons in the developing cerebral cortex.Neurochem Int. 2007 Jul-Sep;51(2-4):121-31. doi: 10.1016/j.neuint.2007.05.006. Epub 2007 May 21. Neurochem Int. 2007. PMID: 17588709 Review.
-
Neuronal migration in the developing cerebral cortex: observations based on real-time imaging.Cereb Cortex. 2003 Jun;13(6):607-11. doi: 10.1093/cercor/13.6.607. Cereb Cortex. 2003. PMID: 12764035 Review.
-
Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain.Nat Neurosci. 2001 Nov;4 Suppl:1177-82. doi: 10.1038/nn749. Nat Neurosci. 2001. PMID: 11687827 Review.
-
Constructing circuits: neurogenesis and migration in the developing neocortex.Epilepsia. 2005;46 Suppl 7:15-21. doi: 10.1111/j.1528-1167.2005.00304.x. Epilepsia. 2005. PMID: 16201991
-
Two modes of radial migration in early development of the cerebral cortex.Nat Neurosci. 2001 Feb;4(2):143-50. doi: 10.1038/83967. Nat Neurosci. 2001. PMID: 11175874
Cited by
-
Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain.Development. 2013 Feb;140(4):906-15. doi: 10.1242/dev.087148. Epub 2013 Jan 16. Development. 2013. PMID: 23325758 Free PMC article.
-
Polarity transitions during neurogenesis and germinal zone exit in the developing central nervous system.Front Cell Neurosci. 2015 Mar 4;9:62. doi: 10.3389/fncel.2015.00062. eCollection 2015. Front Cell Neurosci. 2015. PMID: 25852469 Free PMC article. Review.
-
Making connections in the inner ear: recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells.Semin Cell Dev Biol. 2013 May;24(5):460-9. doi: 10.1016/j.semcdb.2013.04.003. Epub 2013 May 6. Semin Cell Dev Biol. 2013. PMID: 23660234 Free PMC article. Review.
-
Radial glia progenitor polarity in health and disease.Front Cell Dev Biol. 2024 Oct 2;12:1478283. doi: 10.3389/fcell.2024.1478283. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39416687 Free PMC article. Review.
-
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.Neuron. 2010 Jul 15;67(1):33-48. doi: 10.1016/j.neuron.2010.06.002. Neuron. 2010. PMID: 20624590 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
