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. 2002 Jun;70(6):3284-6.
doi: 10.1128/IAI.70.6.3284-3286.2002.

Role of interleukin-18 in host defense against disseminated Candida albicans infection

Rogier J L Stuyt  1 , Mihai G Netea, Ineke Verschueren, Giamila Fantuzzi, Charles A Dinarello, Jos W M Van Der Meer, Bart Jan Kullberg
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Role of interleukin-18 in host defense against disseminated Candida albicans infection

Rogier J L Stuyt et al. Infect Immun. 2002 Jun.

Abstract

In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma.

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Figures

FIG. 1.
FIG. 1.
Circulating IL-18 during disseminated candidiasis. Groups of 10 TNF+/+ LT+/+ and TNF−/− LT−/− mice were injected i.v. with 105 C. albicans CFU. IL-18 concentrations in the serum of TNF+/+ LT+/+ (closed circles) and TNF−/− LT−/− (open triangles) mice were measured by enhanced chemiluminescence at various time points after infection (the experiment was performed twice, with a total of 10 animals per time point). Asterisk, P < 0.05
FIG. 2.
FIG. 2.
The role of endogenous IL-18 in the defense against disseminated candidiasis. CBA mice received 200 μl of either NRS (closed circles) or anti-IL-18 antiserum (open triangles) and were thereafter injected i.v. with 105 C. albicans CFU. Outgrowth of the microorganism in the kidneys was assessed on days 1, 3, and 7 after infection in groups of 10 animals. Asterisk, P < 0.05
FIG. 3.
FIG. 3.
Cytokine concentrations during disseminated candidiasis. CBA mice received 200 μl of either NRS (closed circles) or anti-IL-18 antiserum (open triangles) and were thereafter injected i.v. with 105 C. albicans CFU. Circulating concentrations of IL-1α (A) and IL-6 (B) were measured on days 1, 3, and 7 after infection in subgroups of 10 animals. Asterisk, P < 0.05.
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