Review
doi: 10.1038/nrc746.
Multiple myeloma: evolving genetic events and host interactions
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- PMID: 11990854
- DOI: 10.1038/nrc746
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Review
Multiple myeloma: evolving genetic events and host interactions
Nat Rev Cancer.
2002 Mar.
Free article
Abstract
Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?
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