Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims
- PMID: 11988167
- DOI: 10.1016/s0896-6273(02)00660-8
Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims
Abstract
Five adenosines within the coding sequence of the serotonin 2C receptor (5-HT2C) pre-mRNA are converted to inosines by RNA editing (named A, B, C' (E), C, and D sites). In human prefrontal cortex (PFC), the most abundant 5-HT2C mRNA sequences result from editing at the A site, or from the editing combinations AC'C, ABCD, and ABD. In suicide victims with a history of major depression, C' site editing is significantly increased, D site editing is significantly decreased, and the C site shows a trend toward increased editing. Treatment of mice with the antidepressant drug fluoxetine (Prozac) causes changes in C', C, and D site editing that are exactly opposite to those seen in suicide victims. Thus, one outcome of fluoxetine treatment may be to reverse the abnormalities in 5-HT2C pre-mRNA editing seen in depressed suicide victims.
Comment in
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And now, transcriptomics.Neuron. 2002 Apr 25;34(3):327-8. doi: 10.1016/s0896-6273(02)00680-3. Neuron. 2002. PMID: 11988161
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