A thymic precursor to the NK T cell lineage
- PMID: 11968185
- DOI: 10.1126/science.1069017
A thymic precursor to the NK T cell lineage
Abstract
CD1d-restricted autoreactive natural killer (NK1.1+) T cells function as regulatory cells in various disease conditions. Using improved tetramer tracking methodology, we identified a NK1.1- thymic precursor and followed its differentiation and emigration to tissues by direct cell transfer and in situ cell labeling studies. A major lineage expansion occurred within the thymus after positive selection and before NK receptor expression. Surprisingly, cytokine analysis of the developmental intermediates between NK and NK+ stages showed a T helper cell TH2 to TH1 conversion, suggesting that the regulatory functions of NK T cells may be developmentally controlled. These findings characterize novel thymic and postthymic developmental pathways that expand autoreactive cells and differentiate them into regulatory cells.
Comment in
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Immunology. T before NK.Science. 2002 Apr 19;296(5567):481-2. doi: 10.1126/science.1071492. Science. 2002. PMID: 11964466 No abstract available.
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