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. 2002 Mar;124(1-2):83-92.
doi: 10.1016/s0165-5728(01)00496-9.

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

Takashi Togo  1 , Haruhiko Akiyama, Eizo Iseki, Hiromi Kondo, Kenji Ikeda, Masanori Kato, Tatsuro Oda, Kuniaki Tsuchiya, Kenji Kosaka
Affiliations

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

Takashi Togo et al. J Neuroimmunol. 2002 Mar.

Abstract

We investigated the occurrence of T cells in the brain parenchyma of Alzheimer's disease (AD), non-AD degenerative dementias and controls by semi-quantitative analysis of immunohistochemically stained tissue sections. In all cases, we found at least some T cells. The number of T cells was increased in the majority of AD cases compared with other cases. The phenotype of T cells in the AD brain indicates that they are activated but are not fully differentiated. Antigen-triggered clonal expansion is not likely to take place. Local inflammatory conditions might cause accumulation and activation of T cells in the AD brain.

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