Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Apr;109(8):999-1006.
doi: 10.1172/JCI15468.

Integrins in invasive growth

Cord Brakebusch  1 , Daniel Bouvard, Fabio Stanchi, Takao Sakai, Reinhard Fässler
Affiliations
Review

Integrins in invasive growth

Cord Brakebusch et al. J Clin Invest. 2002 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Major integrin-linked signaling pathways affecting migration. Integrin signaling stimulates Rho GTPases and thereby induces changes in the cytoskeletal organization that are required for cell migration. Ligand binding to integrins also promotes cell contractility through the activation of the tyrosine kinase Erk.
Figure 2
Figure 2
Integrin control of proliferation. Synergistic activation of Ras and Rho GTPases by integrins and growth factors is necessary for cell cycle progression. Activation of Rac1, Cdc42, and RhoA can facilitate activation of Erk via Ras. Erk, as well as JNK and ILK, can induce expression of cyclin D1, thus promoting cell cycle progression. In addition, integrins can promote proliferation by inhibiting cell cycle inhibitors like p21cip and p27kip.
Figure 3
Figure 3
Integrin control of cell survival. Integrin activation of Akt via PI3-K or ILK plays an important role in the antiapoptotic effect of integrin-mediated adhesion. Activation of Erk and JNK likewise contributes to increased cell survival.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mastrangelo AM, Homan SM, Humphries MJ, LaFlamme SE. Amino acid motifs required for isolated β cytoplasmic domains to regulate ‘in trans’ β1 integrin conformation and function in cell attachment. J Cell Sci. 1999;112:217–229. - PubMed
    1. Keely PJ, Rusyn EV, Cox AD, Parise LV. R-Ras signals through specific integrin α cytoplasmic domains to promote migration and invasion of breast epithelial cells. J Cell Biol. 1999;145:1077–1088. - PMC - PubMed
    1. Liu S, Calderwood DA, Ginsberg MH. Integrin cytoplasmic domain-binding proteins. J Cell Sci. 2000;113:3563–3571. - PubMed
    1. Constantin G, et al. Chemokines trigger immediate β2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Immunity. 2000;13:759–769. - PubMed
    1. Danilkovitch-Miagkova A, Zbar B. Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. J Clin Invest. 2002;109:863–867. DOI:10.1172/JCI200215418. - PMC - PubMed

Publication types