Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat
- PMID: 11949770
- DOI: 10.1177/026988110201600112
Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat
Abstract
The tryptophan (TRP) depletion method has been used as a tool to investigate the effects of acute lowered serotonin levels in the brain. In the present study, the effects of this treatment were investigated in rat models of anxiety (open field test, home cage emergence test), depression (forced swimming test, sucrose preference test) and cognition (spatial discrimination learning, sustained attention). It was found that the repeated TRP depletion increased anxiety-related behaviour in the open field test and increased immobility in the forced swimming test. The other behavioural tests did not reveal effects of treatment. TRP levels were decreased in plasma (34%) and hippocampus (33%) but not in the cortex. Stress-induced corticosterone levels were not affected after TRP depletion. The present findings indicate that repeated moderate TRP depletion leads to anxiogenic and depressive-like behaviour in the rat and corroborates the notion of the involvement of serotonin in these behaviours.
Similar articles
-
The effects of acute tryptophan depletion on affective behaviour and cognition in Brown Norway and Sprague Dawley rats.J Psychopharmacol. 2010 Apr;24(4):605-14. doi: 10.1177/0269881108099424. Epub 2008 Dec 12. J Psychopharmacol. 2010. PMID: 19074537
-
Influence of sex and estrous cycle on the effects of acute tryptophan depletion induced by a gelatin-based mixture in adult Wistar rats.Neuroscience. 2007 Jun 29;147(2):304-17. doi: 10.1016/j.neuroscience.2007.04.028. Epub 2007 May 25. Neuroscience. 2007. PMID: 17531394
-
Acute tryptophan depletion induced by a gelatin-based mixture impairs object memory but not affective behavior and spatial learning in the rat.Behav Brain Res. 2004 May 5;151(1-2):53-64. doi: 10.1016/j.bbr.2003.08.002. Behav Brain Res. 2004. PMID: 15084421
-
Acute tryptophan depletion in C57BL/6 mice does not induce central serotonin reduction or affective behavioural changes.Neurochem Int. 2010 Jan;56(1):21-34. doi: 10.1016/j.neuint.2009.08.010. Epub 2009 Aug 28. Neurochem Int. 2010. PMID: 19716853
-
Tryptophan modulation and cognition.Adv Exp Med Biol. 2003;527:207-13. doi: 10.1007/978-1-4615-0135-0_24. Adv Exp Med Biol. 2003. PMID: 15206734 Review.
Cited by
-
Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons: correlation with behavioral pathology.Neuroscience. 2011 Dec 29;199:333-45. doi: 10.1016/j.neuroscience.2011.10.011. Epub 2011 Oct 18. Neuroscience. 2011. PMID: 22033458 Free PMC article.
-
Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats.Amino Acids. 2009 Jul;37(2):349-57. doi: 10.1007/s00726-008-0160-4. Epub 2008 Aug 6. Amino Acids. 2009. PMID: 18683016 Free PMC article.
-
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors.Neuropsychopharmacology. 2015 Jan;40(1):88-112. doi: 10.1038/npp.2014.231. Epub 2014 Sep 2. Neuropsychopharmacology. 2015. PMID: 25178408 Free PMC article. Review.
-
Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus.Neuropsychopharmacology. 2010 Sep;35(10):2083-100. doi: 10.1038/npp.2010.80. Epub 2010 Jun 23. Neuropsychopharmacology. 2010. PMID: 20571484 Free PMC article.
-
On the anxiogenic and anxiolytic nature of long-term cerebral 5-HT depletion following MDMA.Psychopharmacology (Berl). 2002 Aug;162(4):448-50. doi: 10.1007/s00213-002-1158-3. Psychopharmacology (Berl). 2002. PMID: 12224536 No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
