doi: 10.1126/science.1069516.
Epub 2002 Mar 28.
Genetic dissection of transcriptional regulation in budding yeast
Affiliations
- PMID: 11923494
- DOI: 10.1126/science.1069516
Item in Clipboard
Genetic dissection of transcriptional regulation in budding yeast
Science.
.
Abstract
To begin to understand the genetic architecture of natural variation in gene expression, we carried out genetic linkage analysis of genomewide expression patterns in a cross between a laboratory strain and a wild strain of Saccharomyces cerevisiae. Over 1500 genes were differentially expressed between the parent strains. Expression levels of 570 genes were linked to one or more different loci, with most expression levels showing complex inheritance patterns. The loci detected by linkage fell largely into two categories: cis-acting modulators of single genes and trans-acting modulators of many genes. We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function.
Similar articles
-
Influence of low glycolytic activities in gcr1 and gcr2 mutants on the expression of other metabolic pathway genes in Saccharomyces cerevisiae.Yeast. 2005 Jan 30;22(2):111-27. doi: 10.1002/yea.1198. Yeast. 2005. PMID: 15645478
-
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.Nat Genet. 2003 Sep;35(1):57-64. doi: 10.1038/ng1222. Epub 2003 Aug 3. Nat Genet. 2003. PMID: 12897782
-
Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies.Mol Microbiol. 2006 Aug;61(3):704-22. doi: 10.1111/j.1365-2958.2006.05235.x. Epub 2006 Jun 27. Mol Microbiol. 2006. PMID: 16803598
-
Transcriptional networks: reverse-engineering gene regulation on a global scale.Curr Opin Microbiol. 2004 Dec;7(6):638-46. doi: 10.1016/j.mib.2004.10.009. Curr Opin Microbiol. 2004. PMID: 15556037 Review.
-
[Interaction between yeast transcription factor GAL11 and general transcription factors].Tanpakushitsu Kakusan Koso. 1996 Jun;41(8 Suppl):1178-86. Tanpakushitsu Kakusan Koso. 1996. PMID: 8741639 Review. Japanese. No abstract available.
Cited by
-
Sources of gene expression variation in a globally diverse human cohort.Nature. 2024 Aug;632(8023):122-130. doi: 10.1038/s41586-024-07708-2. Epub 2024 Jul 17. Nature. 2024. PMID: 39020179 Free PMC article.
-
Pan-transcriptome reveals a large accessory genome contribution to gene expression variation in yeast.Nat Genet. 2024 Jun;56(6):1278-1287. doi: 10.1038/s41588-024-01769-9. Epub 2024 May 22. Nat Genet. 2024. PMID: 38778243 Free PMC article.
-
Genome-scale analysis of interactions between genetic perturbations and natural variation.Nat Commun. 2024 May 18;15(1):4234. doi: 10.1038/s41467-024-48626-1. Nat Commun. 2024. PMID: 38762544 Free PMC article.
-
Pleiotropy, epistasis and the genetic architecture of quantitative traits.Nat Rev Genet. 2024 Sep;25(9):639-657. doi: 10.1038/s41576-024-00711-3. Epub 2024 Apr 2. Nat Rev Genet. 2024. PMID: 38565962 Review.
-
The fitness trade-off between growth and stress resistance determines the phenotypic landscape.BMC Biol. 2024 Mar 13;22(1):62. doi: 10.1186/s12915-024-01856-7. BMC Biol. 2024. PMID: 38475791 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
