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. 2002 Mar 15;62(6):1876-83.

DNA damage is able to induce senescence in tumor cells in vitro and in vivo

Robert H te Poele  1 , Andrei L Okorokov, Lesley Jardine, Jeffrey Cummings, Simon P Joel
Affiliations
  • PMID: 11912168

DNA damage is able to induce senescence in tumor cells in vitro and in vivo

Robert H te Poele et al. Cancer Res. .

Abstract

Often the use of cytotoxic drugs in cancer therapy results in stable disease rather than regression of the tumor, and this is typically seen as a failure of treatment. We now show that DNA damage is able to induce senescence in tumor cells expressing wild-type p53. We also show that cytotoxics are capable of inducing senescence in tumor tissue in vivo. Our results suggest that p53 and p21 play a central role in the onset of senescence, whereas p16(INK4a) function may be involved in maintaining senescence. Thus, like apoptosis, senescence appears to be a p53-induced cellular response to DNA damage and an important factor in determining treatment outcome.

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