Gene-specific regulation by general translation factors
- PMID: 11909525
- DOI: 10.1016/s0092-8674(02)00642-6
Gene-specific regulation by general translation factors
Abstract
Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. Recent studies have enhanced our understanding of the translation initiation process and helped elucidate how modifications of the general translational machinery regulate gene-specific protein production.
Similar articles
-
Regulation of translation initiation and modulation of cellular physiology.Trends Biochem Sci. 1993 Nov;18(11):429-32. doi: 10.1016/0968-0004(93)90143-b. Trends Biochem Sci. 1993. PMID: 8291089 Review.
-
Involvement of an initiation factor and protein phosphorylation in translational control of GCN4 mRNA.Trends Biochem Sci. 1990 Apr;15(4):148-52. doi: 10.1016/0968-0004(90)90215-w. Trends Biochem Sci. 1990. PMID: 2187295 Review.
-
Regulation of translation in eukaryotic systems.Annu Rev Cell Biol. 1992;8:197-225. doi: 10.1146/annurev.cb.08.110192.001213. Annu Rev Cell Biol. 1992. PMID: 1335743 Review. No abstract available.
-
Diversity of mechanisms in the regulation of translation in prokaryotes and lower eukaryotes.Curr Opin Genet Dev. 1992 Oct;2(5):720-6. doi: 10.1016/s0959-437x(05)80132-7. Curr Opin Genet Dev. 1992. PMID: 1281027 Review.
-
GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.Genes Dev. 1995 Jul 15;9(14):1781-96. doi: 10.1101/gad.9.14.1781. Genes Dev. 1995. PMID: 7542616
Cited by
-
Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells.Cell. 2016 May 5;165(4):990-1001. doi: 10.1016/j.cell.2016.04.040. Cell. 2016. PMID: 27153499 Free PMC article.
-
Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.PLoS One. 2012;7(4):e34412. doi: 10.1371/journal.pone.0034412. Epub 2012 Apr 3. PLoS One. 2012. PMID: 22509299 Free PMC article.
-
Adaptive changes in alphavirus mRNA translation allowed colonization of vertebrate hosts.J Virol. 2012 Sep;86(17):9484-94. doi: 10.1128/JVI.01114-12. Epub 2012 Jul 3. J Virol. 2012. PMID: 22761388 Free PMC article.
-
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.PLoS One. 2012;7(10):e46715. doi: 10.1371/journal.pone.0046715. Epub 2012 Oct 4. PLoS One. 2012. PMID: 23056417 Free PMC article.
-
Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis.Sci Signal. 2016 Apr 26;9(425):ra41. doi: 10.1126/scisignal.aad4949. Sci Signal. 2016. PMID: 27117251 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases