Ribosome as a molecular machine
- PMID: 11904172
- DOI: 10.1016/s0014-5793(02)02309-8
Ribosome as a molecular machine
Abstract
General principles of structure and function of the ribosome are surveyed, and the translating ribosome is regarded as a molecular conveying machine. Two coupled conveying processes, the passing of compact tRNA globules and the drawing of linear mRNA chain through intraribosomal channel, are considered driven by discrete acts of translocation during translation. Instead of mechanical transmission mechanisms and power-stroke 'motors', thermal motion and chemically induced changes in affinities of ribosomal binding sites for their ligands (tRNAs, mRNA, elongation factors) are proposed to underlie all the directional movements within the ribosomal complex. The GTP-dependent catalysis of conformational transitions by elongation factors during translation is also discussed.
Similar articles
-
The ribosome as an RNA-based molecular machine.RNA Biol. 2004 May;1(1):3-9. Epub 2004 May 29. RNA Biol. 2004. PMID: 17194938 Review.
-
Elongation factors on the ribosome.Curr Opin Struct Biol. 2005 Jun;15(3):349-54. doi: 10.1016/j.sbi.2005.05.004. Curr Opin Struct Biol. 2005. PMID: 15922593 Review.
-
Form follows function: structure of an elongation factor G-ribosome complex.Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7237-9. doi: 10.1073/pnas.95.13.7237. Proc Natl Acad Sci U S A. 1998. PMID: 9636131 Free PMC article. No abstract available.
-
The ribosome as a molecular machine: the mechanism of tRNA-mRNA movement in translocation.Biochem Soc Trans. 2011 Apr;39(2):658-62. doi: 10.1042/BST0390658. Biochem Soc Trans. 2011. PMID: 21428957 Review.
-
Dynamics of translation on the ribosome: molecular mechanics of translocation.FEMS Microbiol Rev. 1999 Jun;23(3):317-33. doi: 10.1111/j.1574-6976.1999.tb00402.x. FEMS Microbiol Rev. 1999. PMID: 10371036 Review.
Cited by
-
Ribosomal computing: implementation of the computational method.BMC Bioinformatics. 2024 Oct 3;25(1):321. doi: 10.1186/s12859-024-05945-w. BMC Bioinformatics. 2024. PMID: 39358680 Free PMC article.
-
Alexander Sergeevich Spirin September 4, 1931 - December 30, 2020.RNA. 2021 Feb 5;27(5):vii-ix. doi: 10.1261/rna.078702.121. Online ahead of print. RNA. 2021. PMID: 33547185 Free PMC article. No abstract available.
-
In vitro assembly of semi-artificial molecular machine and its use for detection of DNA damage.J Vis Exp. 2012 Jan 11;(59):e3628. doi: 10.3791/3628. J Vis Exp. 2012. PMID: 22258163 Free PMC article.
-
A model for ribosome translocation based on the alternated displacement of its subunits.Eur Biophys J. 2023 Apr;52(3):175-187. doi: 10.1007/s00249-023-01662-z. Epub 2023 Jun 9. Eur Biophys J. 2023. PMID: 37291414
-
Semi-artificial Fluorescent Molecular Machine for DNA Damage Detection.Nano Lett. 2004 Dec;4(12):2461-6. doi: 10.1021/nl048357e. Nano Lett. 2004. PMID: 17330146 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
