Review
doi: 10.1016/s0958-1669(01)00272-5.
Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins
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- PMID: 11849947
- DOI: 10.1016/s0958-1669(01)00272-5
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Review
Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins
Curr Opin Biotechnol.
2001 Dec.
Abstract
Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.
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