This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Email citation

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 2002 Jan;9(1):3-16.

doi: 10.1016/s1074-5521(02)00092-3.

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

Christina M Grozinger¹, Stuart L Schreiber

Affiliations

PMID: 11841934
DOI: 10.1016/s1074-5521(02)00092-3

Review

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

Christina M Grozinger et al. Chem Biol. 2002 Jan.

. 2002 Jan;9(1):3-16.

doi: 10.1016/s1074-5521(02)00092-3.

Authors

Christina M Grozinger¹, Stuart L Schreiber

Affiliation

¹ Department of Chemistry and Chemical Biology and, Howard Hughes Medical Institute, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.

PMID: 11841934
DOI: 10.1016/s1074-5521(02)00092-3

No abstract available

PubMed Disclaimer

Similar articles

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.
Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. Grozinger CM, et al. J Biol Chem. 2001 Oct 19;276(42):38837-43. doi: 10.1074/jbc.M106779200. Epub 2001 Aug 1. J Biol Chem. 2001. PMID: 11483616
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.
Imai S, Armstrong CM, Kaeberlein M, Guarente L. Imai S, et al. Nature. 2000 Feb 17;403(6771):795-800. doi: 10.1038/35001622. Nature. 2000. PMID: 10693811
dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster.
Barlow AL, van Drunen CM, Johnson CA, Tweedie S, Bird A, Turner BM. Barlow AL, et al. Exp Cell Res. 2001 Apr 15;265(1):90-103. doi: 10.1006/excr.2001.5162. Exp Cell Res. 2001. PMID: 11281647
The molecular biology of the SIR proteins.
Gasser SM, Cockell MM. Gasser SM, et al. Gene. 2001 Nov 14;279(1):1-16. doi: 10.1016/s0378-1119(01)00741-7. Gene. 2001. PMID: 11722841 Review.
The human histone deacetylase family.
Gray SG, Ekström TJ. Gray SG, et al. Exp Cell Res. 2001 Jan 15;262(2):75-83. doi: 10.1006/excr.2000.5080. Exp Cell Res. 2001. PMID: 11139331 Review.

See all similar articles

Cited by

Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors.
Varghese S, Gupta D, Baran T, Jiemjit A, Gore SD, Casero RA Jr, Woster PM. Varghese S, et al. J Med Chem. 2005 Oct 6;48(20):6350-65. doi: 10.1021/jm0505009. J Med Chem. 2005. PMID: 16190761 Free PMC article.
Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat.
Lu H, Pise-Masison CA, Linton R, Park HU, Schiltz RL, Sartorelli V, Brady JN. Lu H, et al. J Virol. 2004 Jul;78(13):6735-43. doi: 10.1128/JVI.78.13.6735-6743.2004. J Virol. 2004. PMID: 15194748 Free PMC article.
Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228.
Mays JR, Restituyo JA, Katzenberger RJ, Wassarman DA, Rajski SR. Mays JR, et al. Tetrahedron Lett. 2007 Jun 25;48(26):4579-4583. doi: 10.1016/j.tetlet.2007.04.123. Tetrahedron Lett. 2007. PMID: 18575573 Free PMC article.
Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line.
Yagi Y, Fushida S, Harada S, Kinoshita J, Makino I, Oyama K, Tajima H, Fujita H, Takamura H, Ninomiya I, Fujimura T, Ohta T, Yashiro M, Hirakawa K. Yagi Y, et al. J Exp Clin Cancer Res. 2010 Nov 17;29(1):149. doi: 10.1186/1756-9966-29-149. J Exp Clin Cancer Res. 2010. PMID: 21080974 Free PMC article.
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription.
Rajendran R, Garva R, Krstic-Demonacos M, Demonacos C. Rajendran R, et al. J Biomed Biotechnol. 2011;2011:368276. doi: 10.1155/2011/368276. Epub 2011 Sep 7. J Biomed Biotechnol. 2011. PMID: 21912480 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- The Lens - Patent Citations Database
Miscellaneous
- NCI CPTAC Assay Portal