Review
doi: 10.1038/nrn731.
Emerging structure of the nicotinic acetylcholine receptors
Affiliations
- PMID: 11836518
- DOI: 10.1038/nrn731
Item in Clipboard
Review
Emerging structure of the nicotinic acetylcholine receptors
Nat Rev Neurosci.
2002 Feb.
Abstract
The conversion of acetylcholine binding into ion conduction across the membrane is becoming more clearly understood in terms of the structure of the receptor and its transitions. A high-resolution structure of a protein that is homologous to the extracellular domain of the receptor has revealed the binding sites and subunit interfaces in great detail. Although the structures of the membrane and cytoplasmic domains are less well determined, the channel lining and the determinants of selectivity have been mapped. The location and structure of the gates, and the coupling between binding sites and gates, remain to be established.
Similar articles
-
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.Nature. 2001 May 17;411(6835):269-76. doi: 10.1038/35077011. Nature. 2001. PMID: 11357122
-
The structure and function of glutamate receptor ion channels.Nat Rev Neurosci. 2002 Feb;3(2):91-101. doi: 10.1038/nrn725. Nat Rev Neurosci. 2002. PMID: 11836517 Review.
-
Mechanisms of channel gating of the ligand-gated ion channel superfamily inferred from protein structure.Exp Physiol. 2004 Mar;89(2):145-53. doi: 10.1113/expphysiol.2003.026815. Epub 2004 Feb 17. Exp Physiol. 2004. PMID: 15123543 Review.
-
Identification of amino acids in the nicotinic acetylcholine receptor agonist binding site and ion channel photolabeled by 4-[(3-trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine, a novel photoaffinity antagonist.Biochemistry. 2003 Jan 21;42(2):271-83. doi: 10.1021/bi0269815. Biochemistry. 2003. PMID: 12525154
-
A touching picture of nicotinic binding.Neuron. 2004 Mar 25;41(6):841-2. doi: 10.1016/s0896-6273(04)00151-5. Neuron. 2004. PMID: 15046715 Review.
Cited by
-
Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor.J Am Chem Soc. 2012 Jul 18;134(28):11474-80. doi: 10.1021/ja3011379. Epub 2012 Jul 9. J Am Chem Soc. 2012. PMID: 22716019 Free PMC article.
-
Alterations in Neuronal Nicotinic Acetylcholine Receptors in the Pathogenesis of Various Cognitive Impairments.CNS Neurosci Ther. 2024 Oct;30(10):e70069. doi: 10.1111/cns.70069. CNS Neurosci Ther. 2024. PMID: 39370620 Free PMC article. Review.
-
Drug Development in Alzheimer's Disease: The Contribution of PET and SPECT.Front Pharmacol. 2016 Mar 31;7:88. doi: 10.3389/fphar.2016.00088. eCollection 2016. Front Pharmacol. 2016. PMID: 27065872 Free PMC article. Review.
-
Stress degradation studies on varenicline tartrate and development of a validated stability-indicating HPLC method.Sci Pharm. 2012 Jan-Mar;80(1):115-26. doi: 10.3797/scipharm.1109-22. Epub 2011 Dec 5. Sci Pharm. 2012. PMID: 22396908 Free PMC article.
-
Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.J Biol Chem. 2013 May 31;288(22):15888-99. doi: 10.1074/jbc.M112.436576. Epub 2013 Apr 12. J Biol Chem. 2013. PMID: 23585571 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
