Review
doi: 10.1038/nrg727.
The complex structure and dynamic evolution of human subtelomeres
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- PMID: 11836503
- DOI: 10.1038/nrg727
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Review
The complex structure and dynamic evolution of human subtelomeres
Nat Rev Genet.
2002 Feb.
Erratum in
- Nat Rev Genet 2002 Mar;3(3):229
Abstract
Subtelomeres are extraordinarily dynamic and variable regions near the ends of chromosomes. They are defined by their unusual structure: patchworks of blocks that are duplicated near the ends of multiple chromosomes. Duplications among subtelomeres have spawned small gene families, making inter-individual variation in subtelomeres a potential source of phenotypic diversity. The ectopic recombination that occurs between subtelomeres might also have a role in reconstituting telomeres in the absence of telomerase. However, the propensity for subtelomeres to interchange is a double-edged sword, as extensive subtelomeric homology can mediate deleterious rearrangements of the ends of chromosomes to cause human disease.
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