Review
doi: 10.1016/s1359-6446(01)02086-4.
Dynamic combinatorial chemistry
Affiliations
- PMID: 11790622
- DOI: 10.1016/s1359-6446(01)02086-4
Item in Clipboard
Review
Dynamic combinatorial chemistry
Drug Discov Today.
.
Abstract
A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional combinatorial chemistry, and that could make a useful addition to the set of combinatorial techniques used in drug discovery.
Similar articles
-
Combinatorial chemistry of beta-hairpins.Mol Divers. 2003;6(2):149-55. doi: 10.1023/b:modi.0000006841.38638.c7. Mol Divers. 2003. PMID: 14761164 Review.
-
Receptor-assisted combinatorial chemistry: thermodynamics and kinetics in drug discovery.Chemistry. 2005 Mar 4;11(6):1708-16. doi: 10.1002/chem.200400371. Chemistry. 2005. PMID: 15565741 Review.
-
The impact of combinatorial methodologies on medicinal chemistry.Curr Top Med Chem. 2004;4(7):653-69. doi: 10.2174/1568026043451113. Curr Top Med Chem. 2004. PMID: 15032680 Review.
-
Overview of combinatorial chemistry.Curr Protoc Pharmacol. 2001 May;Chapter 9:Unit 9.3. doi: 10.1002/0471141755.ph0903s10. Curr Protoc Pharmacol. 2001. PMID: 22293968
-
The discovery of catalytically active peptides through combinatorial chemistry.Curr Opin Chem Biol. 2003 Jun;7(3):409-19. doi: 10.1016/s1367-5931(03)00065-6. Curr Opin Chem Biol. 2003. PMID: 12826130 Review.
Cited by
-
Engineering multilayer chemical networks.Chem Sci. 2019 Jul 29;10(36):8338-8347. doi: 10.1039/c9sc02166c. eCollection 2019 Sep 28. Chem Sci. 2019. PMID: 31803411 Free PMC article.
-
A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.Chembiochem. 2009 Nov 23;10(17):2772-9. doi: 10.1002/cbic.200900537. Chembiochem. 2009. PMID: 19827080 Free PMC article.
-
Comparative molecular surface analysis: a novel tool for drug design and molecular diversity studies.Mol Divers. 2003;7(1):45-59. doi: 10.1023/b:modi.0000006536.02970.f0. Mol Divers. 2003. PMID: 14768903 Review.
-
Supramolecular templating in thermodynamically controlled synthesis.Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):4801-4. doi: 10.1073/pnas.022643699. Epub 2002 Mar 5. Proc Natl Acad Sci U S A. 2002. PMID: 11880602 Free PMC article. No abstract available.
-
Recent advances in DNA-encoded dynamic libraries.RSC Chem Biol. 2022 Feb 17;3(4):407-419. doi: 10.1039/d2cb00007e. eCollection 2022 Apr 6. RSC Chem Biol. 2022. PMID: 35441147 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
