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Review
. 2002 Jan 18;290(2):615-23.
doi: 10.1006/bbrc.2001.6228.

Calcium-binding proteins: intracellular sensors from the calmodulin superfamily

Françoise Haeseleer  1 , Yoshikazu Imanishi, Izabela Sokal, Slawomir Filipek, Krzysztof Palczewski
Affiliations
Review

Calcium-binding proteins: intracellular sensors from the calmodulin superfamily

Françoise Haeseleer et al. Biochem Biophys Res Commun. .

Abstract

In all eukaryotic cells, and particularly in neurons, Ca(2+) ions are important second messengers in a variety of cellular signaling pathways. In the retina, Ca(2+) modulation plays a crucial function in the development of the visual system's neuronal connectivity and a regulatory role in the conversion of the light signal received by photoreceptors into an electrical signal transmitted to the brain. Therefore, the study of retinal Ca(2+)-binding proteins, which frequently mediate Ca(2+) signaling, has given rise to the important discovery of two subfamilies of these proteins, neuronal Ca(2+)-binding proteins (NCBPs) and calcium-binding proteins (CaBPs), that display similarities to calmodulin (CaM). These and other Ca(2+)-binding proteins are integral components of cellular events controlled by Ca(2+). Some members of these subfamilies also play a vital role in signal transduction outside of the retina. The expansion of the CaM-like protein family reveals diversification among Ca(2+)-binding proteins that evolved on the basis of the classic molecule, CaM. A large number of NCBP and CaBP subfamily members would benefit from their potentially specialized role in Ca(2+)-dependent cellular processes. Pinpointing the role of these proteins will be a challenging task for further research.

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